129-Mfsd14atm1Coll/H
| Status | Available to order |
| EMMA ID | EM:15257 |
| Citation information | RRID:IMSR_EM:15257 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129-Mfsd14atm1Coll/H |
| Alternative name | Mfsd14atm1Coll |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mfsd14atm1Coll |
| Gene/Transgene symbol | Mfsd14a |
Information from provider
| Provider | William Colledge |
| Provider affiliation | PDN, University of Cambridge |
| Genetic information | Disruption of the Mfsd14a gene, tagged with lacZ. Deletion of 70 bp of exon 4 of the Mfsd14a locus, which changes the coding frame to one that contains 23 stop codons and terminates translation of the MFSD14A protein at glycine 93. |
| Phenotypic information | Homozygous:Male sterility.Heterozygous:No phenotype. |
| Breeding history | More than 20 generations. |
| References |
|
| Homozygous fertile | females only |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Mfsd14a (Hiat1) gene disruption causes globozoospermia and infertility in male mice.;Doran Joanne, Walters Cara, Kyle Victoria, Wooding Peter, Hammett-Burke Rebecca, Colledge William Henry, ;2016;Reproduction (Cambridge, England);152;91-9; 27107036