CD1.129S2(Cg)-Pax9^tm1.1Hpt/H

Status	Available to order
EMMA ID	EM:15261
Citation information	RRID:IMSR_EM:15261 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	CD1.129S2(Cg)-Pax9^tm1.1Hpt/H
Alternative name	Official: Pax9tm1.1Hpt (MGI:3723638) Published as: Pax9flox (PMID: 17610273)
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Pax9^tm1.1Hpt
Gene/Transgene symbol	Pax9

Information from provider

Provider	Ralf Kist
Provider affiliation	School of Dental Sciences, Newcastle University
Genetic information	To target the Pax9 gene locus, an FRT-flanked neomycin resistance cassette was inserted into Pax9 intron 2; loxP sites were inserted to flank Pax9 exons 1 and 2. This resulted in the Pax9^tm1Hpt (Pax9neo) allele. In vivo FLPe-mediated recombination was then used to remove the neo cassette leaving Pax9 exons 1 and 2 floxed. This resulted in the Pax9^tm1.1Hpt (Pax9flox) allele. Pax9 can be inactivated by crossing Pax9flox mice with cre recombinase driver mice.
Phenotypic information	Homozygous: Mutants can occasionally be smaller and weigh less than wild-type controls. Heterozygous: No discernible phenotype.
Breeding history	Pax9^tm1Hpt (Pax9neo) were initially established on the 129S2/SvPas background. After FLPe-mediated recombination, mice were backcrossed to CD-1 for at least 10 generations.
References	Derivation of a mouse model for conditional inactivation of Pax9.;Kist Ralf, Greally Elizabeth, Peters Heiko, ;2007;Genesis (New York, N.Y. : 2000);45;460-4; 17610273
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Oligodontia / Orphanet_99798

Literature references

Derivation of a mouse model for conditional inactivation of Pax9.;Kist Ralf, Greally Elizabeth, Peters Heiko, ;2007;Genesis (New York, N.Y. : 2000);45;460-4; 17610273

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
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CD1.129S2(Cg)-Pax9tm1.1Hpt/H