C57BL/6NTac-Tnfrsf11b^tm3877Tac/H

Status	Available to order
EMMA ID	EM:15281
Citation information	RRID:IMSR_EM:15281 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Tnfrsf11b^tm3877Tac/H
Alternative name	C57BL/6NTac-Tnfrsf11b tm3877Tac (Tnfrsf11b flox, OPG flox, Osteoprotegerin flox)
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Tnfrsf11b^tm3877Tac
Gene/Transgene symbol	Tnfrsf11b

Information from provider

Provider	Allan Lawrie
Provider affiliation	National Heart and Lung Institute, Imperial College London
Genetic information	The line possesses loxP sites flanking exon 2 of the Tnfrsf11b (osteoprotegerin, OPG) gene (chr. 15). It creates a conditional/constitutive Tnfrsf11b knock-out when crossed with an appropriate cre recombinase-expressing mouse line.
Phenotypic information	Homozygous: Normal size and appearance compared to wild-type C57BL/6NTac mice. Heterozygous: Normal size and appearance compared to wild-type C57BL/6NTac mice.
Breeding history	More than 10 generations of backcrossing to C57BL/6NTac background. Colony then maintained by in-bred homozygote breeding.
References	None available
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)

decreased brain size / IMPC
enlarged kidney / IMPC
decreased body length / IMPC
osteoporosis / IMPC
abnormal gait / IMPC
abnormal skin morphology / IMPC
decreased bone mineral content / IMPC
decreased bone mineral density / IMPC
abnormal bone structure / IMPC
decreased prepulse inhibition / IMPC
anophthalmia / IMPC
corneal opacity / IMPC
abnormal eye morphology / IMPC
abnormal auditory brainstem response / IMPC
abnormal brain morphology / IMPC
decreased locomotor activity / IMPC
increased circulating alkaline phosphatase level / IMPC
small spleen / IMPC
decreased grip strength / IMPC
preweaning lethality, incomplete penetrance / IMPC
increased circulating phosphate level / IMPC
blind uterus / IMPC
abnormal vitreous body morphology / IMPC
abnormal kidney morphology / IMPC

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

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C57BL/6NTac-Tnfrsf11btm3877Tac/H