C57BL/6-Egr2tm1Pwg Tg(Tbx21-AmCyan)B10ZJfz/H

Status

Available to order

EMMA IDEM:15288
Citation informationRRID:IMSR_EM:15288 

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International strain nameC57BL/6-Egr2tm1Pwg Tg(Tbx21-AmCyan)B10ZJfz/H
Alternative nameAmCyanTbet-Egr2 GFP Knockin
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolEgr2tm1Pwg, Tg-AmCyanTbet
Gene/Transgene symbolEgr2, Tg-AmCyanTbet

Information from provider

ProviderSuling Li
Provider affiliationBrunel University
Genetic informationAmCyan-T-bet reporter mouse line (Yu et al., Nat Immunol., 2015) crossed with GFP knock-in (expression under Egr2 promoter) mice (Miao et al., J Exp Med., 2017; MGI allele ID: 6715310, MGI symbol: Egr2tm1Pwg).
Phenotypic informationHomozygous:
na

Heterozygous:
na
Breeding historyAmCyan-T-bet reporter mouse line (Yu et al., Nat Immunol., 2015) crossed with GFP knock-in (expression under Egr2 promoter) mice (Miao et al., 2017, JEM).
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal mandible morphology / MGI
  • tremors / MGI
  • weakness / MGI
  • paralysis / MGI
  • hindlimb paralysis / MGI
  • abnormal myelination / MGI
  • abnormal rhombomere morphology / MGI
  • abnormal motor neuron morphology / MGI
  • abnormal spinal cord morphology / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • abnormal cranial nerve morphology / MGI
  • abnormal trigeminal nerve morphology / MGI
  • abnormal abducens nerve morphology / MGI
  • abnormal facial nerve morphology / MGI
  • abnormal glossopharyngeal nerve morphology / MGI
  • abnormal vagus nerve morphology / MGI
  • abnormal cranial ganglia morphology / MGI
  • abnormal geniculate ganglion morphology / MGI
  • abnormal trigeminal ganglion morphology / MGI
  • abnormal glossopharyngeal ganglion morphology / MGI
  • abnormal vagus ganglion morphology / MGI
  • abnormal Schwann cell morphology / MGI
  • decreased body weight / MGI
  • weight loss / MGI
  • decreased body size / MGI
  • delayed eyelid opening / MGI
  • hypoactivity / MGI
  • impaired coordination / MGI
  • abnormal gait / MGI
  • impaired limb coordination / MGI
  • postnatal growth retardation / MGI
  • respiratory distress / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • abnormal skeleton development / MGI
  • abnormal neural tube morphology / MGI
  • abnormal sciatic nerve morphology / MGI
  • abnormal aortic valve morphology / MGI
  • abnormal somatic nervous system morphology / MGI
  • short tibia / MGI
  • abnormal cochlear ganglion morphology / MGI
  • abnormal bone mineralization / MGI
  • no phenotypic analysis / MGI
  • abnormal long bone epiphyseal plate morphology / MGI
  • short femur / MGI
  • decreased width of hypertrophic chondrocyte zone / MGI
  • abnormal long bone morphology / MGI
  • abnormal bone structure / MGI
  • short radius / MGI
  • fusion of glossopharyngeal and vagus nerve / MGI
  • decreased length of long bones / MGI
  • increased pulmonary respiratory rate / MGI
  • abnormal neuronal migration / MGI
  • abnormal hindbrain development / MGI
  • decreased diameter of long bones / MGI
  • decreased diameter of femur / MGI
  • decreased diameter of radius / MGI
  • decreased diameter of tibia / MGI
  • decreased nerve conduction velocity / MGI
  • enlarged aortic valve / MGI
  • thick aortic valve cusps / MGI
  • thick pulmonary valve cusps / MGI
  • integument phenotype / MGI
  • lethality at weaning, complete penetrance / MGI
  • postnatal lethality, complete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • increased Schwann cell proliferation / MGI
  • decreased rhombomere 3 size / MGI
  • absent rhombomere 3 / MGI
  • decreased rhombomere 5 size / MGI
  • absent rhombomere 5 / MGI
  • decreased rhombomere 6 size / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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