STOCK Slc34a2tm1.1Nhch/Orl
| Status | Available to order |
| EMMA ID | EM:15296 |
| Citation information | RRID:IMSR_EM:15296 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Slc34a2tm1.1Nhch/Orl |
| Alternative name | B6;129-Slc34a2 tm1Nhch (short name: NaPi-llbx64Flp) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Slc34a2tm1.1Nhch |
| Gene/Transgene symbol | Slc34a2 |
Information from provider
| Provider | Nati Hernando |
| Provider affiliation | Physiology, University Zurich |
| Genetic information | loxP sites inserted into intron 9 and exon 13 (the last one downstream the stop codon) of Slc34a2, the gene encoding the sodium/phosphate cotransporter NaPi-IIb. |
| Phenotypic information | Homozygous:No phenotype detected since loxP sites were introduced in non-coding sequences.Heterozygous:No phenotype detected since loxP sites were introduced in non-coding sequences. |
| Breeding history | Homozygous mice breed normally; 4 backcrosses (ca. 94% C57BL/6, 6% 129). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Pulmonary alveolar microlithiasis / Orphanet_60025
Literature references
- Intestinal Depletion of NaPi-IIb/Slc34a2 in Mice: Renal and Hormonal Adaptation.;Hernando Nati, Myakala Komuraiah, Simona Fabia, Knöpfel Thomas, Thomas Linto, Murer Heini, Wagner Carsten A, Biber Jürg, ;2015;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;30;1925-37; 25827490