C;FVB-Tg(LPA,LPAL2,PLG)1Hgc/Biat
| Status | Available to order |
| EMMA ID | EM:15425 |
| Citation information | RRID:IMSR_EM:15425 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C;FVB-Tg(LPA,LPAL2,PLG)1Hgc/Biat |
| Alternative name | tgYAC-apo(a) mouse |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(LPA,LPAL2,PLG)1Hgc |
| Gene/Transgene symbol | Tg(LPA,LPAL2,PLG)1Hgc |
Information from provider
| Provider | Kelly Frazer |
| Provider affiliation | Department of Pediatrics, Institute for Genomic Medicine |
| Genetic information | The mouse strain contains a 110-kb human apo(a) gene surrounded by greater than 60 kb of 5' and 3' flanking DNA. A full description of the creation of the YAC transgenic mouse is published in Frazer KA, Narla G, Zhang LJ and Rubin EM. Nature Genetics 9 (1995) 424-431, and Byrne, C.D., Schwartz, K., Meer, K., Cheng, J.-F. & Lawn, R.M. The human apolipoprotein(a)/plasminogen gene cluster contains a novel homologue transcribed in liver. Atherosclerosis and Thromb. 14, 534-541 (1994). |
| Phenotypic information | Homozygous:The mice have no phenotype - except that they express an apolipoprotein, apo(a), that is found only in primates (humans and apes).Heterozygous:The same as homozygous mice except that the expression (concentration in plasma) is approximately half. |
| Breeding history | The YAC DNA was micro-injected into oocytes of inbred FVB mice in year 1995 and kept since in this background strain. In 2010 we obtained a breeding pair of this mouse strain and backcrossed it into BALB/cByJIco mice from Charles River. Each year we performed 3 inbred crossing and thus there are currently approximately F40 offsprings. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | homozygous BALB/cByJIco males |
Literature references
- The apolipoprotein(a) gene is regulated by sex hormones and acute-phase inducers in YAC transgenic mice.;Frazer K A, Narla G, Zhang J L, Rubin E M, ;1995;Nature genetics;9;424-31; 7795650
- Farnesoid X receptor represses hepatic human APOA gene expression.;Chennamsetty Indumathi, Claudel Thierry, Kostner Karam M, Baghdasaryan Anna, Kratky Dagmar, Levak-Frank Sanja, Frank Sasa, Gonzalez Frank J, Trauner Michael, Kostner Gert M, ;2011;The Journal of clinical investigation;121;3724-34; 21804189
- FGF19 signaling cascade suppresses APOA gene expression.;Chennamsetty Indumathi, Claudel Thierry, Kostner Karam M, Trauner Michael, Kostner Gert M, ;2012;Arteriosclerosis, thrombosis, and vascular biology;32;1220-7; 22267484
- Nicotinic acid inhibits hepatic APOA gene expression: studies in humans and in transgenic mice.;Chennamsetty Indumathi, Kostner Karam M, Claudel Thierry, Vinod Manjula, Frank Sasa, Weiss Thomas S, Trauner Michael, Kostner Gerhard M, ;2012;Journal of lipid research;53;2405-12; 22930813
- Molecular definition of the extreme size polymorphism in apolipoprotein(a).;Lackner C, Cohen J C, Hobbs H H, ;1993;Human molecular genetics;2;933-40; 8395942