C57BL/6N-Wdr62tm1.1Ics/Ics

Status

Available to order

EMMA IDEM:15618
Citation informationRRID:IMSR_EM:15618 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

International strain nameC57BL/6N-Wdr62tm1.1Ics/Ics
Alternative nameWdr62tm1.1Ics (G15)
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolWdr62tm1.1Ics
Gene/Transgene symbolWdr62

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis line was obtained by modification of BD10 in house derived C57BL/6N embryonic stem cells. Exons 4 to 7 (ENSMUSE00000246782 to ENSMUSE00000246761) were floxed. The flipped NeoR cassette was removed by breeding the male chimeras with flp recombinase deleter females. The line was generated on a pure C57BL/6N inbred genetic background. For detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
Viable - the knock-out allele is subviable at the homozygous state

Heterozygous:
DOI: 10.3390/biomedicines10123148
Breeding historyInbred C57BL/6N
References
  • Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.;Meziane Hamid, Birling Marie-Christine, Wendling Olivia, Leblanc Sophie, Dubos Aline, Selloum Mohammed, Pavlovic Guillaume, Sorg Tania, Kalscheuer Vera M, Billuart Pierre, Laumonnier Frédéric, Chelly Jamel, van Bokhoven Hans, Herault Yann, ;2022;Biomedicines;10;; 36551904
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • aspermia / IMPC
  • enlarged lymph nodes / IMPC
  • germ cell defect / IMPC
  • small testis / IMPC
  • decreased prepulse inhibition / IMPC
  • developmental dysplasia / IMPC
  • small kidney / IMPC
  • small seminal vesicle / IMPC
  • increased circulating sodium level / IMPC
  • microphthalmia / IMPC
  • male infertility / IMPC
  • spermatogenesis defect / IMPC
  • hypoplasia / IMPC
MGI phenotypes (gene matching)
  • microcephaly / MGI
  • right pulmonary isomerism / MGI
  • abnormal liver morphology / MGI
  • dextrocardia / MGI
  • mesocardia / MGI
  • thymus hypoplasia / MGI
  • reduced fertility / MGI
  • loss of cortex neurons / MGI
  • abnormal nervous system physiology / MGI
  • abnormal mitosis / MGI
  • heterotaxia / MGI
  • right aortic arch / MGI
  • fetal growth retardation / MGI
  • decreased neuronal precursor cell number / MGI
  • tricuspid valve atresia / MGI
  • thin cerebral cortex / MGI
  • proportional dwarf / MGI
  • abnormal mitotic spindle morphology / MGI
  • abnormal mitotic spindle assembly checkpoint / MGI
  • atrioventricular septal defect / MGI
  • muscular ventricular septal defect / MGI
  • d-loop transposition of the great arteries / MGI
  • double outlet right ventricle, Taussig bing type / MGI
  • dual inferior vena cava / MGI
  • increased cell death / MGI

Literature references

  • Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.;Meziane Hamid, Birling Marie-Christine, Wendling Olivia, Leblanc Sophie, Dubos Aline, Selloum Mohammed, Pavlovic Guillaume, Sorg Tania, Kalscheuer Vera M, Billuart Pierre, Laumonnier Frédéric, Chelly Jamel, van Bokhoven Hans, Herault Yann, ;2022;Biomedicines;10;; 36551904

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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