- aspermia / IMPC
- enlarged lymph nodes / IMPC
- germ cell defect / IMPC
- small testis / IMPC
- decreased prepulse inhibition / IMPC
- developmental dysplasia / IMPC
- small kidney / IMPC
- small seminal vesicle / IMPC
- increased circulating sodium level / IMPC
- microphthalmia / IMPC
- male infertility / IMPC
- spermatogenesis defect / IMPC
- hypoplasia / IMPC
C57BL/6N-Wdr62tm1.1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:15618 |
| Citation information | RRID:IMSR_EM:15618 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Wdr62tm1.1Ics/Ics |
| Alternative name | Wdr62tm1.1Ics (G15) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Wdr62tm1.1Ics |
| Gene/Transgene symbol | Wdr62 |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | This line was obtained by modification of BD10 in house derived C57BL/6N embryonic stem cells. Exons 4 to 7 (ENSMUSE00000246782 to ENSMUSE00000246761) were floxed. The flipped NeoR cassette was removed by breeding the male chimeras with flp recombinase deleter females. The line was generated on a pure C57BL/6N inbred genetic background. For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:Viable - the knock-out allele is subviable at the homozygous stateHeterozygous:DOI: 10.3390/biomedicines10123148 |
| Breeding history | Inbred C57BL/6N |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive primary microcephaly / Orphanet_2512
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- microcephaly / MGI
- right pulmonary isomerism / MGI
- abnormal liver morphology / MGI
- dextrocardia / MGI
- mesocardia / MGI
- thymus hypoplasia / MGI
- reduced fertility / MGI
- loss of cortex neurons / MGI
- abnormal nervous system physiology / MGI
- abnormal mitosis / MGI
- heterotaxia / MGI
- right aortic arch / MGI
- fetal growth retardation / MGI
- decreased neuronal precursor cell number / MGI
- tricuspid valve atresia / MGI
- thin cerebral cortex / MGI
- proportional dwarf / MGI
- abnormal mitotic spindle morphology / MGI
- abnormal mitotic spindle assembly checkpoint / MGI
- atrioventricular septal defect / MGI
- muscular ventricular septal defect / MGI
- d-loop transposition of the great arteries / MGI
- double outlet right ventricle, Taussig bing type / MGI
- dual inferior vena cava / MGI
- increased cell death / MGI
Literature references
- Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.;Meziane Hamid, Birling Marie-Christine, Wendling Olivia, Leblanc Sophie, Dubos Aline, Selloum Mohammed, Pavlovic Guillaume, Sorg Tania, Kalscheuer Vera M, Billuart Pierre, Laumonnier Frédéric, Chelly Jamel, van Bokhoven Hans, Herault Yann, ;2022;Biomedicines;10;; 36551904
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