C57BL/6J-Tg(Fabp4-Vegfb)#Kaali/Oulu
| Status | Available to order |
| EMMA ID | EM:15646 |
| Citation information | RRID:IMSR_EM:15646 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6J-Tg(Fabp4-Vegfb)#Kaali/Oulu |
| Alternative name | aP2-VEGF-B |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Fabp4-Vegfb)#Kaali |
| Gene/Transgene symbol | Tg(Fabp4-Vegfb)#Kaali |
Information from provider
| Provider | Kari Alitalo |
| Provider affiliation | Helsinki University |
| Genetic information | Mice that express the mouse VEGF-B gene downstream of the adipocyte protein 2 promoter |
| Phenotypic information | Homozygous:It has not been tested as mice have always been maintained as heterozygous.Heterozygous:The mice display massive cardiac hypertrophy at adult stage. The observed cardiac hypertrophy is established around postnatal day 7 (P7). The pups are not born in mendelian ratio, where most of the transgenic pups die at birth. Inspection of these dead P0 pups revealed cardiac septal defects of varying severity. |
| Breeding history | Mice have been maintained in C57BL/6JRj (Janvier) background as heterozygous for the transgene. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
Literature references
- VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications.;Robciuc Marius R, Kivelä Riikka, Williams Ian M, de Boer Jan Freark, van Dijk Theo H, Elamaa Harri, Tigistu-Sahle Feven, Molotkov Dmitry, Leppänen Veli-Matti, Käkelä Reijo, Eklund Lauri, Wasserman David H, Groen Albert K, Alitalo Kari, ;2016;Cell metabolism;23;712-24; 27076080
- Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy.;Sultan Ibrahim, Ramste Markus, Peletier Pim, Hemanthakumar Karthik Amudhala, Ramanujam Deepak, Tirronen Annakaisa, von Wright Ylva, Antila Salli, Saharinen Pipsa, Eklund Lauri, Mervaala Eero, Ylä-Herttuala Seppo, Engelhardt Stefan, Kivelä Riikka, Alitalo Kari, ;2024;Circulation research;134;1465-1482; 38655691