B6;FVB-Tg(Myh6-VEGFB)#Ali/Oulu
| Status | Available to order |
| EMMA ID | EM:15648 |
| Citation information | RRID:IMSR_EM:15648 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;FVB-Tg(Myh6-VEGFB)#Ali/Oulu |
| Alternative name | αMHC-VEGF-B |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Myh6-VEGFB)#Ali |
| Gene/Transgene symbol | Tg(Myh6-VEGFB)#Ali |
Information from provider
| Provider | Kari Alitalo |
| Provider affiliation | Helsinki University |
| Genetic information | Mice that express the human VEGF-B gene downstream of the myosin heavy chain alpha promoter. |
| Phenotypic information | Homozygous:Has not been tested as mice have always been maintained as heterozygous.Heterozygous:The mice display physiological-like cardiac hypertrophy at adult stage. The observed cardiac hypertrophy is established around postnatal day 7 (P7). The pups are born in mendelian ratio. |
| Breeding history | Mice have been maintained in C57BL/6JRj (Janvier) background as heterozygous for the transgene. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
Literature references
- Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy.;Sultan Ibrahim, Ramste Markus, Peletier Pim, Hemanthakumar Karthik Amudhala, Ramanujam Deepak, Tirronen Annakaisa, von Wright Ylva, Antila Salli, Saharinen Pipsa, Eklund Lauri, Mervaala Eero, Ylä-Herttuala Seppo, Engelhardt Stefan, Kivelä Riikka, Alitalo Kari, ;2024;Circulation research;134;1465-1482; 38655691
- Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation.;Bry Maija, Kivelä Riikka, Holopainen Tanja, Anisimov Andrey, Tammela Tuomas, Soronen Jarkko, Silvola Johanna, Saraste Antti, Jeltsch Michael, Korpisalo Petra, Carmeliet Peter, Lemström Karl B, Shibuya Masabumi, Ylä-Herttuala Seppo, Alhonen Leena, Mervaala Eero, Andersson Leif C, Knuuti Juhani, Alitalo Kari, ;2010;Circulation;122;1725-33; 20937974
- VEGF-B Promotes Endocardium-Derived Coronary Vessel Development and Cardiac Regeneration.;Räsänen Markus, Sultan Ibrahim, Paech Jennifer, Hemanthakumar Karthik Amudhala, Yu Wei, He Liqun, Tang Juan, Sun Ying, Hlushchuk Ruslan, Huan Xiuzheng, Armstrong Emma, Khoma Oleksiy-Zakhar, Mervaala Eero, Djonov Valentin, Betsholtz Christer, Zhou Bin, Kivelä Riikka, Alitalo Kari, ;2021;Circulation;143;65-77; 33203221