IMPC phenotypes (gene matching)
129-Rap1gap2tm1(IRES-lacZ-neo)Wtsi/WtsiH
| Status | Available to order |
| EMMA ID | EM:15837 |
| Citation information | RRID:IMSR_EM:15837 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129-Rap1gap2tm1(IRES-lacZ-neo)Wtsi/WtsiH |
| Alternative name | 129-Rap1gap2 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Rap1gap2tm1(IRES-lacZ-neo)Wtsi |
| Gene/Transgene symbol | Rap1gap |
Information from provider
| Provider | Seth Grant |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | Information sourced from supplementary data 1 for https://doi.org/10.1101/500389: This knockout mouse strain was created via ES cells to mouse conversion. E14TG2a ES cells were targeted with a vector which replaced 908bp of Rap1gap genomic DNA (X137271961 to X137272599; Ensemble Build 55) with IRES-lacZ-neo cassette in exons 9 and 10 leading to a frameshift mutation between exon 8 and 11. |
| Phenotypic information | Mutant mice showed no discernible overall behavioural difference from wildtypes, with only one behaviour variable, RR memory, significantly increased by this mutation. |
| Breeding history | Mice were maintained by backcrossing onto the 129S5/SvEvBrd background; heterozygous males and females were fertile and used to set up intercrosses to generate homozygous, heterozygous and wildtype mice to study |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |