- decreased locomotor activity / IMPC
- decreased grip strength / IMPC
- decreased body weight / IMPC
- tremors / IMPC
- increased lean body mass / IMPC
- increased circulating sodium level / IMPC
- decreased exploration in new environment / IMPC
- increased bone mineral content / IMPC
- decreased total body fat amount / IMPC
- abnormal behavior / IMPC
- decreased bone mineral content / IMPC
B6J;129-Dlg4tm3.1Grnt/WtsiH
| Status | Available to order |
| EMMA ID | EM:15857 |
| Citation information | RRID:IMSR_EM:15857 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6J;129-Dlg4tm3.1Grnt/WtsiH |
| Alternative name | B6J;129-Dlg4 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Dlg4tm3.1Grnt |
| Gene/Transgene symbol | Dlg4 |
Information from provider
| Provider | Seth Grant |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | Information sourced from PMID: 19455133: The strain carries a Tandem Affinity Purification (TAP) tag inserted upstream of the stop codon in exon 19 along with a floxed neo cassette. The neo cassette was then removed via cre mediated recombination. |
| Breeding history | Maintained as Hom x Hom before backcrossing Homs to C57BL/6J and maintinaing as Het x Het/WT. Line is Hom viable at 20% and Hom fertile. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-specific syndromic intellectual disability / Orphanet_528084
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal sebaceous gland morphology / MGI
- abnormal forebrain morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal social investigation / MGI
- abnormal anxiety-related response / MGI
- increased anxiety-related response / MGI
- decreased anxiety-related response / MGI
- abnormal maternal nurturing / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- increased grooming behavior / MGI
- abnormal spatial learning / MGI
- abnormal contextual conditioning behavior / MGI
- decreased startle reflex / MGI
- impaired balance / MGI
- increased circulating corticosterone level / MGI
- abnormal pain threshold / MGI
- abnormal learning/memory/conditioning / MGI
- abnormal innervation / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal nociception after inflammation / MGI
- decreased vertical activity / MGI
- abnormal discrimination learning / MGI
- abnormal AMPA-mediated synaptic currents / MGI
- abnormal glutamate-mediated receptor currents / MGI
- abnormal NMDA-mediated synaptic currents / MGI
- enhanced paired-pulse facilitation / MGI
- enhanced long term potentiation / MGI
- allodynia / MGI
- nervous system phenotype / MGI
- abnormal synaptic transmission / MGI
- maternal effect / MGI
- decreased stereotypic behavior / MGI
- decreased neurotransmitter release / MGI
- abnormal striatum morphology / MGI
- abnormal synaptic plasticity / MGI
- abnormal spatial working memory / MGI
- enhanced behavioral response to cocaine / MGI
- impaired behavioral response to cocaine / MGI
- abnormal dendritic spine morphology / MGI
- abnormal hippocampus pyramidal cell morphology / MGI
- increased grip strength / MGI
- decreased grip strength / MGI
- increased response to stress-induced hyperthermia / MGI
- reduced AMPA-mediated synaptic currents / MGI
- postnatal lethality, incomplete penetrance / MGI
- decreased vocalization / MGI
Literature references
- Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.;Fernández Esperanza, Collins Mark O, Uren Rachel T, Kopanitsa Maksym V, Komiyama Noboru H, Croning Mike D R, Zografos Lysimachos, Armstrong J Douglas, Choudhary Jyoti S, Grant Seth G N, ;2009;Molecular systems biology;5;269; 19455133
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