IMPC phenotypes (gene matching)
129S5;129P2-Dusp4Gt(XG164)Byg/WtsiH
| Status | Available to order |
| EMMA ID | EM:15873 |
| Citation information | RRID:IMSR_EM:15873 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129S5;129P2-Dusp4Gt(XG164)Byg/WtsiH |
| Alternative name | 129-Dusp4 |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Dusp4Gt(XG164)Byg |
| Gene/Transgene symbol | Dusp4 |
Information from provider
| Provider | Seth Grant |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | Information sourced from supplementary data 1 for dhttps://doi.org/10.1101/500389: This mouse strain was created via ES cells to mouse conversion. The ES cells (XG164, strain 129/Ola) were obtained from BayGenomics (baygenomics.ucsf.edu/). An insertional mutation in Dusp4 (XG164) was inserted in mouse ES cells using gene trap vector pGT0lxr. The gene trap, located in intron 1-2, creates an in-frame fusion between the 5' exons of the trapped gene and a reporter, Beta-geo in exon 1. |
| Phenotypic information | Homozygous:Heterozygous:Mutant mice showed no discernible overall behavioural di↵erence from wildtypes. |
| Breeding history | Maintain by backcrossing to 129S5/SvEvBrd mice. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased caudal vertebrae number / MGI
- abnormal macrophage physiology / MGI
- decreased rib number / MGI
- decreased lumbar vertebrae number / MGI
- decreased thoracic vertebrae number / MGI
- increased susceptibility to parasitic infection / MGI
- increased T cell proliferation / MGI
- immune system phenotype / MGI
- decreased circulating glucose level / MGI
- decreased circulating potassium level / MGI
- increased circulating sodium level / MGI
- decreased circulating sodium level / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- decreased IgG2a level / MGI
- increased IgG1 level / MGI
- increased tumor necrosis factor secretion / MGI
- decreased interferon-gamma secretion / MGI
- increased interleukin-10 secretion / MGI
- decreased interleukin-10 secretion / MGI
- increased interleukin-12 secretion / MGI
- increased interleukin-13 secretion / MGI
- increased interleukin-4 secretion / MGI
- increased interleukin-6 secretion / MGI
- decreased B cell apoptosis / MGI
- increased sacral vertebrae number / MGI