B6.129-Sod1em2.1(SOD1*G93A)Emcf
| Status | Available to order |
| EMMA ID | EM:15895 |
| Citation information | RRID:IMSR_EM:15895 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Sod1em2.1(SOD1*G93A)Emcf |
| Alternative name | B6.129-Sod1 |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Sod1em2.1(SOD1*G93A)Emcf |
| Gene/Transgene symbol | Sod1 |
Information from provider
| Provider | Elizabeth Fisher |
| Provider affiliation | Neuromuscular Diseases, UCL Queen Square Institute of Neurology |
| Genetic information | This strain carries genomic humanization of the murine Sod1 locus with the orthologous sequence from human, commencing at the start ATG in exon1 and ending downstream of the mouse 3' UTR in exon 5. The inserted genomic sequence includes all the coding exons, the human introns and the human 3' UTR. A portion of the human genomic insertion (exons 4 and 5) has been floxed and a mutant version of this sequence harbouring the G93A mutation is included immediately downstream. In the absence of Cre recombination, wild-type humanized SOD1 should be expressed. After Cre recombinase action, a humanized mutant SOD1 G93A should be expressed. |
| Breeding history | Congenic on B6J. Originated on (129X1/SvJ x 129S1/Sv)F1-Kitl+. Injected egg cell background- C57BL/6J |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Amyotrophic lateral sclerosis / Orphanet_803