IMPC phenotypes (gene matching)
B6;129-Tardbpem4(TARDBP*N390)Emcf/H
| Status | Available to order |
| EMMA ID | EM:15898 |
| Citation information | RRID:IMSR_EM:15898 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Tardbpem4(TARDBP*N390)Emcf/H |
| Alternative name | Tardbp |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Tardbpem4(TARDBP*N390D |
| Gene/Transgene symbol | Tardbp |
Information from provider
| Provider | Elizabeth Fisher |
| Provider affiliation | Neuromuscular Diseases, UCL Queen Square Institute of Neurology |
| Genetic information | Point mutation (N390D) made by CRISPR/Cas9 gene editing introduced onto existing transgenic humanised tardbp allele, Tardbpem2.1(TARDBP)Emcf . |
| Breeding history | Congenic on B6J. Originated on (129X1/SvJ x 129S1/Sv)F1-Kitl+. Injected egg cell background- C57BL/6J |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased body weight / MGI
- abnormal locomotor behavior / MGI
- impaired coordination / MGI
- abnormal eating behavior / MGI
- polyphagia / MGI
- abnormal object recognition memory / MGI
- limb grasping / MGI
- abnormal learning/memory/conditioning / MGI
- abnormal motor capabilities/coordination/movement / MGI
- increased vertical activity / MGI
- no phenotypic analysis / MGI
- impaired muscle relaxation / MGI
- abnormal GABAergic neuron morphology / MGI
- nervous system phenotype / MGI
- decreased stereotypic behavior / MGI
- abnormal brain interneuron morphology / MGI
- abnormal muscle tone / MGI
- behavior/neurological phenotype / MGI
- slow postnatal weight gain / MGI
- decreased grip strength / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- absent inner cell mass proliferation / MGI
- embryonic lethality prior to organogenesis / MGI
- abnormal cognition / MGI
- cognitive inflexibility / MGI