C57BL/6N-C9orf72em2.1Tjcu/H

Status

Available to order

EMMA IDEM:15902
Citation informationRRID:IMSR_EM:15902 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-C9orf72em2.1Tjcu/H
Alternative nameC9orf72
Strain typeEndonuclease-mediated
Allele/Transgene symbolC9orf72em2.1Tjcu
Gene/Transgene symbolC9orf72

Information from provider

ProviderThomas Cunningham
Provider affiliationInstitute of Prion Diseases, University College London
Genetic informationThis strain carries a 'partially' humanized allele of C9orf72. The C9orf72 gene is humanized from the start of intron 1 through to the ATG start codon in exon 2. All mouse promotor sequences and UTRs have been retained. The allele also carries a hexanucleotide pathogenic repeat expansion within the humanized intron 1. The humanized allele contains a PiggyBac ITR-flanked selection cassette.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • epithelial hyperplasia / IMPC
  • hyperplasia / IMPC
  • decreased total body fat amount / IMPC
  • enlarged spleen / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • chronic inflammation / IMPC
  • abnormal spleen morphology / IMPC
  • lymphoid hyperplasia / IMPC
  • abnormal vertebral arch morphology / IMPC
  • increased lean body mass / IMPC
  • increased spleen weight / IMPC
  • myeloid hyperplasia / IMPC
  • inflammation / IMPC
  • small testis / IMPC
  • enlarged lymph nodes / IMPC
  • acute inflammation / IMPC

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

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