C57BL/6-C9orf72em1.1Tjcu/H

Status

Available to order

EMMA IDEM:15903
Citation informationRRID:IMSR_EM:15903 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6-C9orf72em1.1Tjcu/H
Alternative nameC9orf72
Strain typeEndonuclease-mediated
Allele/Transgene symbolC9orf72em2Tjcu
Gene/Transgene symbolC9orf72

Information from provider

ProviderThomas Cunningham
Provider affiliationInstitute of Prion Diseases, University College London
Genetic informationThese mice carry a completely' humanized C9orf72 gene (humanisation spans from human intron 1 to the STOP codon; Chr9:27548236-27573708 [GRCh38]) replacing the synonymous mouse genomic sequence chr4:35192881-35225928 [mm10]), with a pathogenic hexanucleotide repeat in intron 1.The construct contains a Neomycin selection cassette, flanked by PiggyBac ITRs. The line should be crossed with a PBase expressing mouse to remove the selection cassette.
Breeding historyMixed background: C57BL/6N x C57BL/6J
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • epithelial hyperplasia / IMPC
  • hyperplasia / IMPC
  • decreased total body fat amount / IMPC
  • enlarged spleen / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • chronic inflammation / IMPC
  • abnormal spleen morphology / IMPC
  • lymphoid hyperplasia / IMPC
  • abnormal vertebral arch morphology / IMPC
  • increased lean body mass / IMPC
  • increased spleen weight / IMPC
  • myeloid hyperplasia / IMPC
  • inflammation / IMPC
  • small testis / IMPC
  • enlarged lymph nodes / IMPC
  • acute inflammation / IMPC

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Practical information

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