C3H.C-Atmingpg6/H
| Status | Available to order |
| EMMA ID | EM:15943 |
| Citation information | RRID:IMSR_EM:15943 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3H.C-Atmingpg6/H |
| Alternative name | C3H.C-Atmin |
| Strain type | Induced Mutant Strains |
| Allele/Transgene symbol | Atmingpg6 |
| Gene/Transgene symbol | Atmin |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This strain carries an ENU mutagenesis induced a T to A point mutation in the third zinc finger domain that results in the amino acid susbtitution of cystine for serine at position 183 (C183S). This mutation is predicted to disrupt zinc binding and the ability of the protein to act as a transcription factor. |
| Phenotypic information | Mice display pulmonary, tracheal, and oesophageal agenesis, small, hypoplastic lungs, and occasionally disply spinal bifida. |
| Breeding history | Original mutant was the offspring of a BALB/cAnn male that received ENU mated to a C3H/HeH female. Congenic on C3H/HeH |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | no |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Mouse mutagenesis identifies novel roles for left-right patterning genes in pulmonary, craniofacial, ocular, and limb development.;Ermakov Alexander, Stevens Jonathan L, Whitehill Elaine, Robson Joan E, Pieles Guido, Brooker Debra, Goggolidou Paraskevi, Powles-Glover Nicola, Hacker Terry, Young Stephen R, Dear Neil, Hirst Elizabeth, Tymowska-Lalanne Zuzanna, Briscoe James, Bhattacharya Shoumo, Norris Dominic P, ;2009;Developmental dynamics : an official publication of the American Association of Anatomists;238;581-94; 19235720