B6.C3-Bcat2mpc91H/H
| Status | Available to order |
| EMMA ID | EM:15946 |
| Citation information | RRID:IMSR_EM:15946 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.C3-Bcat2mpc91H/H |
| Alternative name | B6.C3-Bcat2 |
| Strain type | Induced Mutant Strains |
| Allele/Transgene symbol | Bcat2mpc91H |
| Gene/Transgene symbol | Bcat2 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | Dim arose in a pedigree in which the G3 offspring had headbobs, full body tremors and cardiac dysfunction. These phenotypes were subsequently segregated. |
| Phenotypic information | The DIM mice only carry the cardiac dysfunction. Mice from this pedigree need careful welfare assessment daily, as the phenotype is very subtle. Mice will show signs of squinting of their eyes, and will have a flattened hind gait and move slowly when disturbed. This pedigree may be useful to investigate diseases associated with cardiac abnormalities. The onset of end point cardiac dysfunction may be dependent on genetic background.In our hands the mice reach their end point on average at E32 in C3H.Pde6b mice and on average at E43 in C57BL/6J mice. |
| Breeding history | Congenic on C57BL/6J |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | no |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.;Potter Paul K, Bowl Michael R, Jeyarajan Prashanthini, Wisby Laura, Blease Andrew, Goldsworthy Michelle E, Simon Michelle M, Greenaway Simon, Michel Vincent, Barnard Alun, Aguilar Carlos, Agnew Thomas, Banks Gareth, Blake Andrew, Chessum Lauren, Dorning Joanne, Falcone Sara, Goosey Laurence, Harris Shelley, Haynes Andy, Heise Ines, Hillier Rosie, Hough Tertius, Hoslin Angela, Hutchison Marie, King Ruairidh, Kumar Saumya, Lad Heena V, Law Gemma, MacLaren Robert E, Morse Susan, Nicol Thomas, Parker Andrew, Pickford Karen, Sethi Siddharth, Starbuck Becky, Stelma Femke, Cheeseman Michael, Cross Sally H, Foster Russell G, Jackson Ian J, Peirson Stuart N, Thakker Rajesh V, Vincent Tonia, Scudamore Cheryl, Wells Sara, El-Amraoui Aziz, Petit Christine, Acevedo-Arozena Abraham, Nolan Patrick M, Cox Roger, Mallon Anne-Marie, Brown Steve D M, ;2016;Nature communications;7;12444; 27534441