C57BL/6NTac-Hhip^em1H/H

Status	Available to order
EMMA ID	EM:15954
Citation information	RRID:IMSR_EM:15954 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Hhip^em1H/H
Alternative name	C57BL/6NTac-Hhip/H
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Hhip^em1H
Gene/Transgene symbol	Hhip

Information from provider

Provider	MRC, Medical Research Council
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This is a CRISPR/Cas9 induced mutation deleting 1061 nucleotides from Hhip gene, across critical exons ENSMUSE00000212344 and ENSMUSE00000464439, to introduce a frameshift that results in a premature stop codon/null allele. The stock was generated at MRC Harwell via microinjection of CRISPR/Cas9 reagents into 1-cell stage embryos.
Breeding history	Maintained on C57BL/6N
References	None available
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	not known
Immunocompromised	not known

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)

decreased mean corpuscular hemoglobin concentration / IMPC

MGI phenotypes (gene matching)

abnormal stomach glandular epithelium morphology / MGI
abnormal spleen morphology / MGI
small spleen / MGI
abnormal lung morphology / MGI
respiratory failure / MGI
abnormal neural tube morphology / MGI
abnormal pulmonary alveolar duct morphology / MGI
left pulmonary isomerism / MGI
small lung / MGI
abnormal pancreas development / MGI
abnormal pancreatic islet morphology / MGI
small pancreatic islets / MGI
disorganized pancreatic islets / MGI
primary atelectasis / MGI
neonatal lethality, complete penetrance / MGI
decreased pancreatic beta cell proliferation / MGI
ectopic pancreas / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

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C57BL/6NTac-Hhipem1H/H