| Status | Available to order |
| EMMA ID | EM:15960 |
| Citation information | RRID:IMSR_EM:15960 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6J.Cg-Wlstm-Kba/Orl |
| Alternative name | Wls-cKO-KBa |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Wlstm1.1 |
| Gene/Transgene symbol | Wls |
| Provider | Konrad Basler |
| Provider affiliation | DMLS, University of Zurich |
| Genetic information | Conditional allele of Wls (Gpr177) gene. The cre-mediated recombination results in no Wls mRNA and protein, thus the secretion of Wnt ligands is blocked. Two loxP sites flanking the first exon of Wls were introduced together with neo resistance cassette, which was later removed by crossing to flp deleter strain (post-flp). |
| Phenotypic information | Homozygous:no phenotypeHeterozygous:no phenotype |
| Breeding history | Bruce 4 ES cells. After removal of the resistance cassette the strain was crossed with C57BL/6J (in particular: B6JCrl1) for more than 15 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males |
