C57BL/6J-Sec31aem1H/H

Status

Available to order

EMMA IDEM:16012
Citation informationRRID:IMSR_EM:16012 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6J-Sec31aem1H/H
Alternative nameC57BL/6J-Sec31a/H
Strain typeEndonuclease-mediated
Allele/Transgene symbolSec31aem1H
Gene/Transgene symbolSec31a

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis strain carries a CRISPR induced deletion of 1055 nt from Sec31a gene, encompassing a critical exon to induce a premature stop codon and a null allele. Deletion of 1055 nt including exon ENSMUSE00001292836.
Breeding historyCoisogenic on C57BL/6J
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased circulating aspartate transaminase level / IMPC
  • embryonic lethality prior to organogenesis / IMPC
  • abnormal locomotor behavior / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased circulating alanine transaminase level / IMPC
  • increased grip strength / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
  • decreased fasting circulating glucose level / IMPC

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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Practical information

Genotyping protocol

Example health report
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