C3H.C-Dnah11lrn5/H

Status

Available to order

EMMA IDEM:16024
Citation informationRRID:IMSR_EM:16024 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC3H.C-Dnah11lrn5/H
Alternative nameC3H.C-Dnah11lrn5/H
Strain typeInduced Mutant Strains
Allele/Transgene symbolDnahlrm5
Gene/Transgene symbolDnah11

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis strain is an ENU derived point mutation mutant in Dnah11 displaying a significant level of situs inversus. The line may be useful to study body patterning and organ development.
Phenotypic informationThe strain presents phenotypes related to left-right body symmetry. Some of the alterations observed are present in certain human disease syndromes. The mutants also have defects in ciliogenesis.
Breeding historyCongenic on C3H/HeH
References
  • Mouse mutagenesis identifies novel roles for left-right patterning genes in pulmonary, craniofacial, ocular, and limb development.;Ermakov Alexander, Stevens Jonathan L, Whitehill Elaine, Robson Joan E, Pieles Guido, Brooker Debra, Goggolidou Paraskevi, Powles-Glover Nicola, Hacker Terry, Young Stephen R, Dear Neil, Hirst Elizabeth, Tymowska-Lalanne Zuzanna, Briscoe James, Bhattacharya Shoumo, Norris Dominic P, ;2009;Developmental dynamics : an official publication of the American Association of Anatomists;238;581-94; 19235720
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal heart morphology / MGI
  • heart right ventricle hypertrophy / MGI
  • double outlet right ventricle / MGI
  • abnormal mitral valve morphology / MGI
  • abnormal intestine morphology / MGI
  • hydronephrosis / MGI
  • right pulmonary isomerism / MGI
  • left-sided isomerism / MGI
  • abnormal autopod morphology / MGI
  • abnormal liver morphology / MGI
  • dextrocardia / MGI
  • mesocardia / MGI
  • abnormal spleen morphology / MGI
  • spleen hypoplasia / MGI
  • anophthalmia / MGI
  • microphthalmia / MGI
  • abnormal left-right axis patterning / MGI
  • abnormal embryo implantation / MGI
  • edema / MGI
  • reduced fertility / MGI
  • decreased litter size / MGI
  • abnormal respiration / MGI
  • perinatal lethality / MGI
  • abnormal cardiovascular system morphology / MGI
  • abnormal kidney morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal myocardial trabeculae morphology / MGI
  • heart left ventricle hypertrophy / MGI
  • micrognathia / MGI
  • situs inversus / MGI
  • abnormal heart atrium morphology / MGI
  • left pulmonary isomerism / MGI
  • accessory spleen / MGI
  • decreased heart right ventricle size / MGI
  • kidney cysts / MGI
  • duplex kidney / MGI
  • abnormal primitive node morphology / MGI
  • abnormal motile primary cilium morphology / MGI
  • heterotaxia / MGI
  • interrupted aortic arch / MGI
  • right aortic arch / MGI
  • abnormal respiratory conducting tube morphology / MGI
  • abnormal vertebral column morphology / MGI
  • abnormal thoracic cavity morphology / MGI
  • abnormal biliary tract morphology / MGI
  • right atrial isomerism / MGI
  • abnormal inferior vena cava morphology / MGI
  • pulmonary valve stenosis / MGI
  • left atrial isomerism / MGI
  • polycystic kidney / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • abnormal motile primary cilium physiology / MGI
  • ventricular septal defect / MGI
  • ostium primum atrial septal defect / MGI
  • atrioventricular septal defect / MGI
  • complete atrioventricular septal defect / MGI
  • muscular ventricular septal defect / MGI
  • pulmonary artery hypoplasia / MGI
  • vascular ring / MGI
  • abnormal heart atrium auricular region morphology / MGI
  • common atrioventricular valve / MGI
  • abnormal hepatic portal vein morphology / MGI
  • abnormal stomach position or orientation / MGI
  • right-sided stomach / MGI
  • abnormal lung lobe morphology / MGI
  • abnormal respiratory motile cilium physiology / MGI
  • abdominal situs inversus / MGI
  • abdominal situs ambiguus / MGI
  • situs inversus totalis / MGI
  • situs inversus with levocardia / MGI
  • superior-inferior ventricles / MGI
  • biventricular, discordant atrioventricular connection / MGI
  • biventricular, ambiguous atrioventricular connection / MGI
  • immotile respiratory cilia / MGI
  • d-loop transposition of the great arteries / MGI
  • double outlet right ventricle, ventricular defect committed to aorta / MGI
  • dual inferior vena cava / MGI
  • isolation of the left subclavian artery / MGI
  • absent nodal flow / MGI

Literature references

  • Mouse mutagenesis identifies novel roles for left-right patterning genes in pulmonary, craniofacial, ocular, and limb development.;Ermakov Alexander, Stevens Jonathan L, Whitehill Elaine, Robson Joan E, Pieles Guido, Brooker Debra, Goggolidou Paraskevi, Powles-Glover Nicola, Hacker Terry, Young Stephen R, Dear Neil, Hirst Elizabeth, Tymowska-Lalanne Zuzanna, Briscoe James, Bhattacharya Shoumo, Norris Dominic P, ;2009;Developmental dynamics : an official publication of the American Association of Anatomists;238;581-94; 19235720

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.​
Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).