IMPC phenotypes (gene matching)
B6N;129S2(B6J)-Ackr3tm1.1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:16057 |
| Citation information | RRID:IMSR_EM:16057 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N;129S2(B6J)-Ackr3tm1.1Ics/Ics |
| Alternative name | Ackr3tm1.1Ics/Ics |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Ackr3tm1.1Ics |
| Gene/Transgene symbol | Ackr3 |
Information from provider
| Provider | Mireille Rossel |
| Provider affiliation | INSERM U1198, Laboratoire Mécanismes Moléculaires dans les Démences Neurodégénératives (MMDN) |
| Genetic information | A FRT-loxP-NeoR-FRT cassette followed by a loxP site was inserted upstream of exon 2 (Ackr3-201, GCRm39) and a second loxP site was inserted downstream exon 2; flp-mediated recombination removed the selection cassette and left exons 2 floxed. |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | Line backcrossed 2 times in C57BL/6NTac. Current background: C57BL/6J 6.25%, 129/SvPas 25%, C57BL/6N 68.75% |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal heart morphology / MGI
- overriding aortic valve / MGI
- enlarged heart / MGI
- heart hyperplasia / MGI
- abnormal interventricular septum morphology / MGI
- abnormal atrioventricular cushion morphology / MGI
- abnormal cardiovascular system physiology / MGI
- cyanosis / MGI
- abnormal blood vessel morphology / MGI
- abnormal atrial thrombosis / MGI
- lung inflammation / MGI
- hemorrhage / MGI
- respiratory distress / MGI
- premature death / MGI
- abnormal semilunar valve morphology / MGI
- abnormal aortic valve morphology / MGI
- abnormal pulmonary valve morphology / MGI
- dilated heart right ventricle / MGI
- dilated heart atrium / MGI
- cardiac fibrosis / MGI
- nervous system phenotype / MGI
- myocardial fiber degeneration / MGI
- digestive/alimentary phenotype / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- pulmonary fibrosis / MGI
- calcified aortic valve / MGI
- aortic valve stenosis / MGI
- abnormal cardiac outflow tract development / MGI
- pulmonary valve stenosis / MGI
- decreased marginal zone B cell number / MGI
- decreased survivor rate / MGI
- ventricular septal defect / MGI
- atrial septal defect / MGI
- perimembraneous ventricular septal defect / MGI
- abnormal heart and great artery attachment / MGI
- thick aortic valve / MGI
- thick pulmonary valve / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
Literature references
- CXCR7 Receptor Controls the Maintenance of Subpial Positioning of Cajal-Retzius Cells.;Trousse Françoise, Poluch Sylvie, Pierani Alessandra, Dutriaux Annie, Bock Hans H, Nagasawa Takashi, Verdier Jean-Michel, Rossel Mireille, ;2015;Cerebral cortex (New York, N.Y. : 1991);25;3446-57; 25085881