B6N.129(B6J)-Arxtm1.1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:16059 |
| Citation information | RRID:IMSR_EM:16059 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N.129(B6J)-Arxtm1.1Ics/Ics |
| Alternative name | Arxtm1.1Ics/Ics |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Arxtm1.1Ics |
| Gene/Transgene symbol | Arx |
Information from provider
| Provider | Gaëlle Friocourt |
| Provider affiliation | UMR1101, IBRBS, Faculté de médecine et sciences de la Santé, Université de Bretagne Occidentale (UBO) |
| Genetic information | Exon 2 (ENSMUSE00000403876, Arx-201, GRCm39) was replaced with one in which murine nucleotides 459-698 were replaced by the corresponding human sequence (amino acids 79-160), containing a 24 bp duplication in the polyalanine tract (c.428_451dup24) generating a partially humanized exon 2. A loxP-flanked neomycin resistance cassette follows the modified exon 2 and was removed via cre-mediated recombination. |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | Line backcrossed 8 times in C57BL/6N. Current background: C57BL/6J 0.1402%, C57BL/6N 99.579%, 129/SvPas 0.2808% |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Literature references
- A new mouse model of ARX dup24 recapitulates the patients' behavioral and fine motor alterations.;Dubos Aline, Meziane Hamid, Iacono Giovanni, Curie Aurore, Riet Fabrice, Martin Christelle, Loaëc Nadège, Birling Marie-Christine, Selloum Mohammed, Normand Elisabeth, Pavlovic Guillaume, Sorg Tania, Stunnenberg Henk G, Chelly Jamel, Humeau Yann, Friocourt Gaëlle, Hérault Yann, ;2018;Human molecular genetics;27;2138-2153; 29659809