B6N(B6J)-Atp6ap2^tm1.1Ics/Ics

Status	Available to order
EMMA ID	EM:16061
Citation information	RRID:IMSR_EM:16061 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6N(B6J)-Atp6ap2^tm1.1Ics/Ics
Alternative name	Atp6ap2tm1.1Ics/Ics
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Atp6ap2^tm1.1Ics
Gene/Transgene symbol	Atp6ap2

Information from provider

Provider	Genevieve Nguyen
Provider affiliation	INSERM and Collèege de France ‘Early Development and Pathologies’ Center for Interdisciplinary Rese
Genetic information	A loxP site was inserted upstream of exon 2 (Atp6ap2-201, GRCm39). A second loxP site followed by a FRT-NeoR-loxP-FRT cassette was inserted upstream of exon 3; flp-mediated recombination removed the selection cassette and left exon 2 floxed.
Phenotypic information	Homozygous: N/A Heterozygous: N/A
Breeding history	Line backcrossed 3 times in C57BL/6NTac. Current background: C57BL/6J 1.5625%, C57BL/6N 12.5%, C57BL/6NTac 85.8375%
References	Prorenin receptor is essential for podocyte autophagy and survival.;Riediger Fabian, Quack Ivo, Qadri Fatimunnisa, Hartleben Björn, Park Joon-Keun, Potthoff Sebastian A, Sohn Dennis, Sihn Gabin, Rousselle Anthony, Fokuhl Verena, Maschke Ulrike, Purfürst Bettina, Schneider Wolfgang, Rump Lars C, Luft Friedrich C, Dechend Ralf, Bader Michael, Huber Tobias B, Nguyen Genevieve, Muller Dominik N, ;2011;Journal of the American Society of Nephrology : JASN;22;2193-202; 22034640
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Literature references

Prorenin receptor is essential for podocyte autophagy and survival.;Riediger Fabian, Quack Ivo, Qadri Fatimunnisa, Hartleben Björn, Park Joon-Keun, Potthoff Sebastian A, Sohn Dennis, Sihn Gabin, Rousselle Anthony, Fokuhl Verena, Maschke Ulrike, Purfürst Bettina, Schneider Wolfgang, Rump Lars C, Luft Friedrich C, Dechend Ralf, Bader Michael, Huber Tobias B, Nguyen Genevieve, Muller Dominik N, ;2011;Journal of the American Society of Nephrology : JASN;22;2193-202; 22034640

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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B6N(B6J)-Atp6ap2tm1.1Ics/Ics