- increased spleen weight / IMPC
- increased neutrophil cell number / IMPC
- increased circulating aspartate transaminase level / IMPC
- decreased circulating serum albumin level / IMPC
- increased heart weight / IMPC
- decreased freezing behavior / IMPC
- preweaning lethality, complete penetrance / IMPC
- increased circulating alanine transaminase level / IMPC
- decreased circulating alkaline phosphatase level / IMPC
C57BL/6N-Glrbtm1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:16066 |
| Citation information | RRID:IMSR_EM:16066 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Glrbtm1Ics/Ics |
| Alternative name | Glrbtm1Ics/Ics |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Glrbtm1Ics |
| Gene/Transgene symbol | Glrb |
Information from provider
| Provider | Christian Specht |
| Provider affiliation | Inserm U1195 / Université Paris-Saclay, Unité DHNS – Maladies et Hormones du Système Nerveux |
| Genetic information | The targeting cassette inserted the coding sequence of the mutated coral-derived green-to-red photoconvertible fluorescent reporter protein (mEos4b) after the signal peptide leader sequence. A self-excising neomycin selection cassette is absent from the final allele. |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | Pure C57BL/6N genetic background. Current background: C57BL/6NCrl 100% |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- fragile skeleton / MGI
- impaired fertilization / MGI
- enlarged adrenal glands / MGI
- muscle spasm / MGI
- tremors / MGI
- abnormal Purkinje cell morphology / MGI
- abnormal spinal cord morphology / MGI
- abnormal dorsal root ganglion morphology / MGI
- abnormal spinal nerve morphology / MGI
- decreased body size / MGI
- abnormal maternal nurturing / MGI
- abnormal gait / MGI
- short stride length / MGI
- increased startle reflex / MGI
- abnormal posture / MGI
- limb grasping / MGI
- impaired swimming / MGI
- impaired righting response / MGI
- edema / MGI
- hemorrhage / MGI
- reduced male fertility / MGI
- abnormal motor capabilities/coordination/movement / MGI
- muscle hypertonia / MGI
- abnormal intervertebral disk morphology / MGI
- impaired acrosome reaction / MGI
- abnormal vertebral column morphology / MGI
- abnormal spinal cord ventral horn morphology / MGI
- hyperekplexia / MGI
- abnormal adrenal cortex morphology / MGI
- abnormal brain dura mater morphology / MGI
- postnatal lethality, incomplete penetrance / MGI
- preweaning lethality, complete penetrance / MGI
Literature references
- Identification of a stereotypic molecular arrangement of endogenous glycine receptors at spinal cord synapses.;Maynard Stephanie A, Rostaing Philippe, Schaefer Natascha, Gemin Olivier, Candat Adrien, Dumoulin Andréa, Villmann Carmen, Triller Antoine, Specht Christian G, ;2021;eLife;10;; 34878402
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