B6;129(B6J)-Pik3r4tm1.1Mpnd/Ics
| Status | Available to order |
| EMMA ID | EM:16069 |
| Citation information | RRID:IMSR_EM:16069 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129(B6J)-Pik3r4tm1.1Mpnd/Ics |
| Alternative name | Pik3r4tm1.1Mpnd/Ics |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Pik3r4tm1.1Mpnd |
| Gene/Transgene symbol | Pik3r4 |
Information from provider
| Provider | Mario Pende |
| Provider affiliation | Institut Necker-Enfants Malades (INEM), INSERM U1151 / CNRS UMR 8253 |
| Genetic information | A loxP site was inserted into intron 1. A second loxP site followed by a FRT-NeoR-LoxP-FRT casette was inserted inton intron 2; flp-mediated recombination removed the selection cassette and left exons 2 (Pik3r4-201, GRCm39) floxed. |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | Line backcrossed 3 times in C57BL/6N. Current background: C57BL/6J 3.12%, 129/SvPas 12.5%, C57BL/6NTac 84.375%. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Literature references
- Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease.;Nemazanyy Ivan, Blaauw Bert, Paolini Cecilia, Caillaud Catherine, Protasi Feliciano, Mueller Amelie, Proikas-Cezanne Tassula, Russell Ryan C, Guan Kun-Liang, Nishino Ichizo, Sandri Marco, Pende Mario, Panasyuk Ganna, ;2013;EMBO molecular medicine;5;870-90; 23630012