B6N;129(B6J)-Rab4btm1.1Ics/Ics

Status

Available to order

EMMA IDEM:16071
Citation informationRRID:IMSR_EM:16071 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6N;129(B6J)-Rab4btm1.1Ics/Ics
Alternative nameRab4btm1.1Ics/Ics
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolRab4btm1.1Ics
Gene/Transgene symbolRab4b

Information from provider

ProviderMireille Cormont
Provider affiliationCentre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d
Genetic informationA loxP site was inserted upstream of exon 2 (Rab4b-201, GRCm39). An second loxP followed by a FRT-NeoR-loxP-FRT cassette was inserted downstream of exon 3; flp-mediated recombination removed the selection cassette and left exons 2-3 floxed.
Phenotypic informationHomozygous:
N/A

Heterozygous:
N/A
Breeding historyLine backcrossed 3 times in C57BL/6N. Current background: C57BL/6J 12.5%, 129/SvPas 12.5%, C57BL/6NTac 75%
References
  • Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance.;Gilleron Jérôme, Bouget Gwennaëlle, Ivanov Stoyan, Meziat Cindy, Ceppo Franck, Vergoni Bastien, Djedaini Mansour, Soprani Antoine, Dumas Karine, Jacquel Arnaud, Yvan-Charvet Laurent, Venteclef Nicolas, Tanti Jean-François, Cormont Mireille, ;2018;Cell reports;25;3329-3341.e5; 30566860
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased circulating creatinine level / IMPC
  • increased circulating alkaline phosphatase level / IMPC

Literature references

  • Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance.;Gilleron Jérôme, Bouget Gwennaëlle, Ivanov Stoyan, Meziat Cindy, Ceppo Franck, Vergoni Bastien, Djedaini Mansour, Soprani Antoine, Dumas Karine, Jacquel Arnaud, Yvan-Charvet Laurent, Venteclef Nicolas, Tanti Jean-François, Cormont Mireille, ;2018;Cell reports;25;3329-3341.e5; 30566860

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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