IMPC phenotypes (gene matching)
- decreased circulating calcium level / IMPC
C57BL/6N-Shank3tm1.1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:16154 |
| Citation information | RRID:IMSR_EM:16154 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Shank3tm1.1Ics/Ics |
| Alternative name | Shank3tm1.1Ics/Ics |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Shank3tm1.1Ics |
| Gene/Transgene symbol | Shank3 |
Information from provider
| Provider | Fabrice Raynaud |
| Provider affiliation | Dpt Neurobiologie, IGF, UMR5203 |
| Genetic information | The targeted vector (with an auto-excision floxed neomycin resistance cassette and a 1.5 kb fragment corresponding to the fusion of the Venus reporter tag sequence) was inserted at the beginning of exon 1 of the Shank3 gene, just after the ATG start codon. The floxed selection cassette was excised in the germline chimera mice. The reporter is to tag exclusively the endogenous Shank3 variants that are produced by the first promoter, i.e. variants of the Shank3a isoform only. |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | 100% C57BL/6N (C57BL/6NCrl 75%, C57BL/6NTac 25%). |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal autopod morphology / MGI
- thalamus hyperplasia / MGI
- skin lesions / MGI
- increased body weight / MGI
- decreased body weight / MGI
- increased aggression towards mice / MGI
- abnormal social investigation / MGI
- social withdrawal / MGI
- increased anxiety-related response / MGI
- decreased anxiety-related response / MGI
- hyperactivity / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- increased stereotypic behavior / MGI
- abnormal response to new environment / MGI
- decreased exploration in new environment / MGI
- increased grooming behavior / MGI
- abnormal object recognition memory / MGI
- abnormal spatial learning / MGI
- reduced long term potentiation / MGI
- reduced long term depression / MGI
- abnormal startle reflex / MGI
- increased startle reflex / MGI
- decreased startle reflex / MGI
- abnormal motor coordination/balance / MGI
- impaired righting response / MGI
- abnormal vocalization / MGI
- abnormal long term depression / MGI
- impaired synaptic plasticity / MGI
- reduced NMDA-mediated synaptic currents / MGI
- abnormal motor capabilities/coordination/movement / MGI
- abnormal brain commissure morphology / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal nervous system electrophysiology / MGI
- abnormal social/conspecific interaction / MGI
- increased vertical activity / MGI
- decreased vertical activity / MGI
- increased thigmotaxis / MGI
- abnormal long term object recognition memory / MGI
- abnormal motor learning / MGI
- abnormal conditioned emotional response / MGI
- abnormal glutamate-mediated receptor currents / MGI
- abnormal excitatory postsynaptic currents / MGI
- abnormal excitatory postsynaptic potential / MGI
- decreased synaptic depression / MGI
- decreased post-tetanic potentiation / MGI
- no phenotypic analysis / MGI
- abnormal response to novelty / MGI
- abnormal response to novel object / MGI
- abnormal single cell response / MGI
- nervous system phenotype / MGI
- abnormal synaptic transmission / MGI
- abnormal ear development / MGI
- decreased thermal nociceptive threshold / MGI
- abnormal striatum morphology / MGI
- abnormal miniature excitatory postsynaptic currents / MGI
- abnormal paired-pulse inhibition / MGI
- abnormal neuron physiology / MGI
- abnormal behavior / MGI
- behavior/neurological phenotype / MGI
- taste/olfaction phenotype / MGI
- hyporesponsive to tactile stimuli / MGI
- abnormal basal ganglion morphology / MGI
- abnormal brain white matter morphology / MGI
- abnormal brain internal capsule morphology / MGI
- abnormal cingulum morphology / MGI
- small hippocampus / MGI
- abnormal spatial reference memory / MGI
- abnormal medium spiny neuron morphology / MGI
- induced hyperactivity / MGI
- environmentally induced seizures / MGI
- abnormal miniature inhibitory postsynaptic currents / MGI
- enhanced contextual conditioning behavior / MGI
- abnormal synapse morphology / MGI
- abnormal odor adaptation / MGI
- abnormal spinal cord commissure morphology / MGI
- abnormal dendritic spine morphology / MGI
- abnormal olfactory lobe morphology / MGI
- abnormal cerebellar peduncle morphology / MGI
- decreased grip strength / MGI
- integument phenotype / MGI
- lethality, incomplete penetrance / MGI
- abnormal allogrooming behavior / MGI
- decreased excitatory postsynaptic current amplitude / MGI
- abnormal innate avoidance response / MGI
- impaired spatial learning / MGI
- impaired learning / MGI
- decreased amygdala size / MGI
- photophobia / MGI
- decreased vocalization / MGI
- abnormal postsynaptic density morphology / MGI
Literature references
- The Shank3Venus/Venus knock in mouse enables isoform-specific functional studies of Shank3a.;Bouquier Nathalie, Sakkaki Sophie, Raynaud Fabrice, Hemonnot-Girard Anne-Laure, Seube Vincent, Compan Vincent, Bertaso Federica, Perroy Julie, Moutin Enora, ;2022;Frontiers in neuroscience;16;1081010; 36570823