- abnormal spleen morphology / IMPC
- abnormal kidney morphology / IMPC
- preweaning lethality, complete penetrance / IMPC
- abnormal placenta vasculature / IMPC
- abnormal placenta morphology / IMPC
- enlarged spleen / IMPC
- enlarged kidney / IMPC
- cataract / IMPC
- hydrometra / IMPC
- microphthalmia / IMPC
- abnormal vitreous body morphology / IMPC
B6N(Cg)-Slit2tm1.1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:16157 |
| Citation information | RRID:IMSR_EM:16157 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N(Cg)-Slit2tm1.1Ics/Ics |
| Alternative name | Slit2tm1.1Ics/Ics |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Slit2tm1.1Ics |
| Gene/Transgene symbol | Slit2 |
Information from provider
| Provider | Alain Chedotal |
| Provider affiliation | Institut de la vision |
| Genetic information | A LoxP site was inserted into intron 7. A second LoxP site followed by an FRT flanked neomycin resistance were inserted into intron 8. The neo cassette was removed through subsequent flp-mediated recombination (MGI:2158498), leaving a conditional-ready allele with exon 8 (ENSMUSE00001269610; GRCm39, Slit2-208) floxed. |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | 73.4% C57BL/6N; the line was backcrossed 2 times with C57BL/6N mice (C57BL/6N 73.43%, FVB/N 0.78%, 129/SvPas 25%, SJL/J 0.78%). |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
IMPC phenotypes (gene matching)
Literature references
- Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization.;Rama Nicolas, Dubrac Alexandre, Mathivet Thomas, Ní Chárthaigh Róisín-Ana, Genet Gael, Cristofaro Brunella, Pibouin-Fragner Laurence, Ma Le, Eichmann Anne, Chédotal Alain, ;2015;Nature medicine;21;483-91; 25894826
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