B6N(Cg)-Elk3tm1.1Ics/Ics

Status

Available to order

EMMA IDEM:16158
Citation informationRRID:IMSR_EM:16158 

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International strain nameB6N(Cg)-Elk3tm1.1Ics/Ics
Alternative nameElk3tm1.1Ics/Ics
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolElk3tm1.1Ics
Gene/Transgene symbolElk3

Information from provider

ProviderChristian Gross
Provider affiliationIGBMC
Genetic informationA loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 1; flp-mediated recombination removed the selection cassette and left exon 1 floxed.
Phenotypic informationHomozygous:
N/A

Heterozygous:
N/A
Breeding history60.15% C57BL/6N; the line was backcrossed 2 times with C57BL/6 mice (C57BL/6N 60.15%; C57BL/6J 12.5; FVB/N 1.17%; 129/SvPas 25%; SJL/J 1.17%).
References
  • Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.;Weinl Christine, Wasylyk Christine, Garcia Garrido Marina, Sothilingam Vithiyanjali, Beck Susanne C, Riehle Heidemarie, Stritt Christine, Roux Michel J, Seeliger Mathias W, Wasylyk Bohdan, Nordheim Alfred, ;2014;PloS one;9;e107048; 25203538
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased prepulse inhibition / IMPC
  • abnormal retina blood vessel pattern / IMPC
  • abnormal eye morphology / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • increased circulating cholesterol level / IMPC
  • abnormal retina vasculature morphology / IMPC
MGI phenotypes (gene matching)
  • abnormal blood vessel physiology / MGI
  • hypoactivity / MGI
  • abnormal cardiovascular system physiology / MGI
  • respiratory failure / MGI
  • respiratory distress / MGI
  • premature death / MGI
  • abnormal retinal vasculature morphology / MGI
  • no phenotypic analysis / MGI
  • chylothorax / MGI
  • lymphangiectasis / MGI
  • cardiovascular system phenotype / MGI
  • vision/eye phenotype / MGI
  • decreased angiogenesis / MGI
  • abnormal vascular endothelial cell morphology / MGI
  • abnormal retinal blood vessel morphology / MGI
  • abnormal pleura morphology / MGI
  • postnatal lethality, incomplete penetrance / MGI

Literature references

  • Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.;Weinl Christine, Wasylyk Christine, Garcia Garrido Marina, Sothilingam Vithiyanjali, Beck Susanne C, Riehle Heidemarie, Stritt Christine, Roux Michel J, Seeliger Mathias W, Wasylyk Bohdan, Nordheim Alfred, ;2014;PloS one;9;e107048; 25203538

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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