- decreased prepulse inhibition / IMPC
- abnormal retina blood vessel pattern / IMPC
- abnormal eye morphology / IMPC
- increased circulating alkaline phosphatase level / IMPC
- increased circulating HDL cholesterol level / IMPC
- increased circulating cholesterol level / IMPC
- abnormal retina vasculature morphology / IMPC
B6N(Cg)-Elk3tm1.1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:16158 |
| Citation information | RRID:IMSR_EM:16158 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N(Cg)-Elk3tm1.1Ics/Ics |
| Alternative name | Elk3tm1.1Ics/Ics |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Elk3tm1.1Ics |
| Gene/Transgene symbol | Elk3 |
Information from provider
| Provider | Christian Gross |
| Provider affiliation | IGBMC |
| Genetic information | A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 1; flp-mediated recombination removed the selection cassette and left exon 1 floxed. |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | 60.15% C57BL/6N; the line was backcrossed 2 times with C57BL/6 mice (C57BL/6N 60.15%; C57BL/6J 12.5; FVB/N 1.17%; 129/SvPas 25%; SJL/J 1.17%). |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal blood vessel physiology / MGI
- hypoactivity / MGI
- abnormal cardiovascular system physiology / MGI
- respiratory failure / MGI
- respiratory distress / MGI
- premature death / MGI
- abnormal retinal vasculature morphology / MGI
- no phenotypic analysis / MGI
- chylothorax / MGI
- lymphangiectasis / MGI
- cardiovascular system phenotype / MGI
- vision/eye phenotype / MGI
- decreased angiogenesis / MGI
- abnormal vascular endothelial cell morphology / MGI
- abnormal retinal blood vessel morphology / MGI
- abnormal pleura morphology / MGI
- postnatal lethality, incomplete penetrance / MGI
Literature references
- Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.;Weinl Christine, Wasylyk Christine, Garcia Garrido Marina, Sothilingam Vithiyanjali, Beck Susanne C, Riehle Heidemarie, Stritt Christine, Roux Michel J, Seeliger Mathias W, Wasylyk Bohdan, Nordheim Alfred, ;2014;PloS one;9;e107048; 25203538
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