IMPC phenotypes (gene matching)
B6N;129(B6J)-Htttm2.1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:16163 |
| Citation information | RRID:IMSR_EM:16163 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N;129(B6J)-Htttm2.1Ics/Ics |
| Alternative name | Htttm2.1Ics/Ics |
| Strain type | Targeted Mutant Strains : Point mutation |
| Allele/Transgene symbol | Htttm2.1Ics |
| Gene/Transgene symbol | Htt |
Information from provider
| Provider | Sandrine Humbert |
| Provider affiliation | Université Grenoble Alpes, Grenoble Institut des Neurosciences (GIN) – INSERM U1216 |
| Genetic information | Nucleotide substitutions (AGC to GAC) result in the amino acid substitution of aspartic acid for serine at position 421 (S421D); cre-mediated recombination removed the selection cassette. |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | 50% C57BL/6N; the line was backcrossed 2 times with C57BL/6N (C57BL/6 4.68, C57BL/6J 20.31, 129/SvPas 25%, C57BL/6NTac 50%). |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Literature references
- Unraveling the Role of Huntingtin in Breast Cancer Metastasis.;Thion Morgane S, McGuire John R, Sousa Cristovao M, Fuhrmann Laetitia, Fitamant Julien, Leboucher Sophie, Vacher Sophie, du Montcel Sophie Tezenas, Bièche Ivan, Bernet Agnès, Mehlen Patrick, Vincent-Salomon Anne, Humbert Sandrine, ;2015;Journal of the National Cancer Institute;107;; 26293574