- decreased mean corpuscular volume / IMPC
- increased bone mineral content / IMPC
- abnormal bone mineralization / IMPC
- decreased granulocyte number / IMPC
- decreased mean corpuscular hemoglobin concentration / IMPC
- abnormal bone structure / IMPC
- decreased circulating glucose level / IMPC
- increased circulating creatinine level / IMPC
- decreased heart weight / IMPC
B6N;129S2(Cg)-Eif2b5tm1.1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:16182 |
| Citation information | RRID:IMSR_EM:16182 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N;129S2(Cg)-Eif2b5tm1.1Ics/Ics |
| Alternative name | Eif2b5tm1.1Ics/Ics |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Eif2b5tm1.1Ics |
| Gene/Transgene symbol | Eif2b5 |
Information from provider
| Provider | Anne Fogli |
| Provider affiliation | UFR de Pharmacie / UFR de Médecine et des Professions paramédicales TSA 50400 |
| Genetic information | A loxP site was inserted into intron 2 and second loxP site followed by an FRT site-flanked neomycin resistance gene cassette were inserted into intron 7. The neo cassette was removed through subsequent flp-mediated recombination (MGI:2158498), leaving a conditional-ready allele with floxed exon 3-7 (GRCm39, Eif2b5-201). |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | The line was backcrossed 3 times with C57BL/6N mice (129S2/SvPas 12.5%, C57BL/6NTac 87.5%). |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Congenital or early infantile CACH syndrome / Orphanet_157713
- Late infantile CACH syndrome / Orphanet_157716
- Ovarioleukodystrophy / Orphanet_99853
- Juvenile or adult CACH syndrome / Orphanet_157719
- Cree leukoencephalopathy / Orphanet_99854
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal forebrain morphology / MGI
- abnormal myelination / MGI
- demyelination / MGI
- sporadic seizures / MGI
- decreased body weight / MGI
- abnormal retina morphology / MGI
- ataxia / MGI
- impaired coordination / MGI
- premature death / MGI
- abnormal astrocyte morphology / MGI
- ectopic Bergmann glia cells / MGI
- abnormal locomotor activation / MGI
- abnormal microglial cell physiology / MGI
- abnormal retinal outer nuclear layer morphology / MGI
- abnormal retinal inner nuclear layer morphology / MGI
- abnormal axon morphology / MGI
- decreased percent body fat/body weight / MGI
- brain vacuoles / MGI
- abnormal brain white matter morphology / MGI
- abnormal brain internal capsule morphology / MGI
- thin retinal inner plexiform layer / MGI
- abnormal physiological response to xenobiotic / MGI
- abnormal astrocyte physiology / MGI
- decreased oligodendrocyte number / MGI
- abnormal cerebellum white matter morphology / MGI
- decreased grip strength / MGI
- increased oligodendrocyte number / MGI
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