C57BL/6N-Ftxtm1.1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:16185 |
| Citation information | RRID:IMSR_EM:16185 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Ftxtm1.1Ics/Ics |
| Alternative name | Ftxtm1.1Ics/Ics |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Ftxtm1.1Ics |
| Gene/Transgene symbol | Ftx |
Information from provider
| Provider | Claire Rougeulle |
| Provider affiliation | Université Paris Cité, Bâtiment Lamarck, CNRS – Epigenetics and Cell Fate – UMR 7216 |
| Genetic information | A loxP site and an F3 site-flanked hygromycin resistance gene cassette were inserted upstream of exon 1 (ENSMUSE00000779650). An FRT site-flanked neomycin resistance gene cassette and a second loxP site were inserted into intron 2 (downstream of exon ENSMUSE00000838436). The hygro and neo cassettes were removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with 12.7 kb targeted region, including the Ftx promoter region and floxed exons 1-2. |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | C57BL/6NTac 100% |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | yes female |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Literature references
- Altered X-chromosome inactivation predisposes to autoimmunity.;Huret Christophe, Ferrayé Léa, David Antoine, Mohamed Myriame, Valentin Nicolas, Charlotte Frédéric, Savignac Magali, Goodhardt Michele, Guéry Jean-Charles, Rougeulle Claire, Morey Céline, ;2024;Science advances;10;eadn6537; 38701219