C57BL/6N-Ftx^tm1.2Ics/Ics

Status	Available to order
EMMA ID	EM:16186
Citation information	RRID:IMSR_EM:16186 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-Ftx^tm1.2Ics/Ics
Alternative name	Ftxtm1.2Ics/Ics
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Ftx^tm1.2Ics
Gene/Transgene symbol	Ftx

Information from provider

Provider	Claire Rougeulle
Provider affiliation	Université Paris Cité, Bâtiment Lamarck, CNRS – Epigenetics and Cell Fate – UMR 7216
Genetic information	A loxP site and an F3 site-flanked hygromycin resistance gene cassette were inserted upstream of exon 1 (ENSMUSE00000779650). An FRT site-flanked neomycin resistance gene cassette and a second loxP site were inserted into intron 2 (downstream of exon ENSMUSE00000838436). The hygro and neo cassettes were removed through subsequent flp-mediated recombination and the 12.7 kb targeted region, including the Ftx promoter region and exons 1-2, was deleted through subsequent cre-mediated recombination.
Phenotypic information	Homozygous: N/A Heterozygous: N/A
Breeding history	C57BL/6N 0.95%, C57BL/6NTac 99.05%
References	Altered X-chromosome inactivation predisposes to autoimmunity.;Huret Christophe, Ferrayé Léa, David Antoine, Mohamed Myriame, Valentin Nicolas, Charlotte Frédéric, Savignac Magali, Goodhardt Michele, Guéry Jean-Charles, Rougeulle Claire, Morey Céline, ;2024;Science advances;10;eadn6537; 38701219
Homozygous fertile	not known
Homozygous viable	yes female
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Literature references

Altered X-chromosome inactivation predisposes to autoimmunity.;Huret Christophe, Ferrayé Léa, David Antoine, Mohamed Myriame, Valentin Nicolas, Charlotte Frédéric, Savignac Magali, Goodhardt Michele, Guéry Jean-Charles, Rougeulle Claire, Morey Céline, ;2024;Science advances;10;eadn6537; 38701219

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.
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C57BL/6N-Ftxtm1.2Ics/Ics