C57BL/6N-Nxnl2tm1.1(KOMP)Vlcg/Ics

Status

Available to order

EMMA IDEM:16194
Citation informationRRID:IMSR_EM:16194 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Nxnl2tm1.1(KOMP)Vlcg/Ics
Alternative nameNxnl2tm1.1(KOMP)Vlcg/Ics
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolNxnl2tm1.1(KOMP)Vlcg
Gene/Transgene symbolNxnl2

Information from provider

ProviderThierry Léveillard
Provider affiliationDépartement de Génétique, Institut de la Vision, INSERM UM 80 / CNRS UMR 7210 / Sorbonne Université
Genetic informationThe insertion of KOMP-Velocigene cassette ZEN-Ub1 created a deletion of 3474 bp size between positions 51325362-51328835 of Chromosome 13 (Build GRCm39). The neo cassette was removed by subsequent cre-mediated recombination.
Phenotypic informationHomozygous:
N/A

Heterozygous:
N/A
Breeding historyC57BL/6N 1.37%, C57BL/6NTac 98.63%
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal thymus morphology / IMPC
  • enlarged spleen / IMPC
  • enlarged thymus / IMPC
  • abnormal spleen morphology / IMPC
  • abnormal coat/ hair morphology / IMPC
  • decreased neutrophil cell number / IMPC
  • decreased lean body mass / IMPC
  • abnormal skeletal muscle morphology / IMPC
MGI phenotypes (gene matching)
  • no phenotypic analysis / MGI
  • abnormal rod electrophysiology / MGI
  • abnormal cone electrophysiology / MGI
  • abnormal olfactory sensory neuron morphology / MGI
  • decreased retinal cone cell number / MGI
  • impaired olfaction / MGI
  • short photoreceptor outer segment / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.​
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