- abnormal vitreous body morphology / IMPC
- increased circulating alkaline phosphatase level / IMPC
- abnormal retina outer nuclear layer morphology / IMPC
- decreased lean body mass / IMPC
- increased lymphocyte cell number / IMPC
- increased circulating creatinine level / IMPC
- abnormal eye anterior chamber depth / IMPC
- decreased total retina thickness / IMPC
C57BL/6N-Rspo1tm2b(KOMP)Wtsi/Ics
| Status | Available to order |
| EMMA ID | EM:16198 |
| Citation information | RRID:IMSR_EM:16198 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Rspo1tm2b(KOMP)Wtsi/Ics |
| Alternative name | Rspo1tm2b(KOMP)Wtsi/Ics |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Rspo1tm2b(KOMP)Wtsi |
| Gene/Transgene symbol | Rspo1 |
Information from provider
| Provider | Marie-Christine CHABOISSIER |
| Provider affiliation | |
| Genetic information | We used the KOMP ES clone EPD0720_2_D03. The cre-mediated excision of the parental Rspo1tm2a(KOMP)Wtsi allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | C57BL/6N 0.03%, C57BL/6NCrl 85.94%, C57BL/6NTac 14.03% |
| References | None available |
| Homozygous fertile | males only |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
IMPC phenotypes (allele matching)
IMPC phenotypes (gene matching)
- increased lean body mass / IMPC
- increased circulating creatinine level / IMPC
- abnormal testis morphology / IMPC
- increased lymphocyte cell number / IMPC
- increased grip strength / IMPC
- decreased brain weight / IMPC
- decreased total body fat amount / IMPC
- small testis / IMPC
- decreased lean body mass / IMPC
- abnormal eye anterior chamber depth / IMPC
- abnormal retina outer nuclear layer morphology / IMPC
- increased bone mineral content / IMPC
- decreased total retina thickness / IMPC
- abnormal vitreous body morphology / IMPC
- abnormal kidney morphology / IMPC
- female infertility / IMPC
- abnormal vibrissa morphology / IMPC
- increased circulating alkaline phosphatase level / IMPC
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