C57BL/6N-Tnfsf4tm1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:16203 |
| Citation information | RRID:IMSR_EM:16203 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Tnfsf4tm1Ics/Ics |
| Alternative name | Tnfsf4tm1Ics/Ics |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Tnfsf4tm1Ics |
| Gene/Transgene symbol | Tnfsf4 |
Information from provider
| Provider | Li Mei |
| Provider affiliation | IGBMC |
| Genetic information | The following elements were inserted into intron 2 to create this knockout-first allele: an FRT site, the En2 intron, sequence coding for 2A self-cleaving peptide, mTagBFP2 reporter gene coding sequence, SV40 poly(A) signal sequence, a loxP site, a neomycin resistance gene cassette, a second FRT site and a second loxP site. A third loxP site was inserted into intron 3. Exon 3 (ENSMUSE00000161960) is thus flanked by loxP sites. A "conditional-ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knock-out mouse. If cre expression occurs without flp expression, a reporter knock-out mouse will be created. |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | C57BL/6NCrl 100% |
| References |
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Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Literature references
- TSLP promotes GATA3-expressing effector regulatory T cells via DC2 derived from transitional DCs.;Guivarch Marine, Meyer Pierre, Braud Antoine, Marschall Pierre, Perrin Alicia, Verdenet Alexis, Vu Manh Thien Phong, Santa Pauline, Sisirak Vanja, Zhang Ya-Li, Flatter Eric, Ye Tao, Jung Matthieu, Birling Marie-Christine, Hener Pierre, Segaud Justine, German Beatriz, Lipsker Dan, Dalod Marc, Li Mei, ;2026;Nature immunology;27;348-363; 41593243