| Status | Available to order |
| EMMA ID | EM:16204 |
| Citation information | RRID:IMSR_EM:16204 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Zbtb24tm1.1Ics/Ics |
| Alternative name | Zbtb24tm1.1Ics/Ics |
| Strain type | Targeted Mutant Strains : Point mutation |
| Allele/Transgene symbol | Zbtb24tm1.1Ics |
| Gene/Transgene symbol | Zbtb24 |
| Provider | Claire Francastel |
| Provider affiliation | Bâtiment Lamarck B, UMR 7216 – Épigénétique et Destin Cellulaire |
| Genetic information | Two nucleotides (TA) were deleted from histidine codon 132 and serine codon 133 (CAtaGC) (c.396_397del) in exon 2, leading to a frameshift and premature stop codon (p.H132Qfs*21). A loxP site-flanked neo resistance gene and protamine promotor-driven cre gene cassette were inserted into and auto-excised from intron 2. The mutation is the equivalent of a human mutation associated with ICF2 syndrome (Immunodeficiency with Centromeric instability and Facial anomalies 2; OMIM #614069). |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | C57BL/6NCrl 75%, C57BL/6NTac 25% |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Orphanet associated rare diseases, based on orthologous gene matching
