| Status | Available to order |
| EMMA ID | EM:16219 |
| Citation information | RRID:IMSR_EM:16219 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Nedd4ltm1.1Ics/Ics |
| Alternative name | Nedd4ltm1.1Ics/Ics |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Nedd4ltm1.1Ics |
| Gene/Transgene symbol | Nedd4l |
| Provider | Jamel Chelly |
| Provider affiliation | IGBMC |
| Genetic information | We inserted a loxP site intron 28. In intron 29, we inserted a Lox511 site, a inverted chimeric human intron-degenerated Ex29 with the mutation of interest, a inverted loxP site, a FRT flanked neomycin resistance gene cassette and a second inverted Lox511 site. The neo cassette was removed through subsequent flp-mediated recombination, leading to a conditional point-mutation allele which will change an arginine to a glutamine (c.2693G>A, p.R898Q) in exon 29 (ENSMUSE00000143555) after cre-mediated recombination. |
| Phenotypic information | Homozygous:N/AHeterozygous:N/A |
| Breeding history | 100% C57BL/6N (C57BL/6NCrl 99,22% C57BL/6NTac 0,78%) |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Orphanet associated rare diseases, based on orthologous gene matching
