BALB/cN-Nxnl1^tm1.1Ics/Ics

Status	Available to order
EMMA ID	EM:16222
Citation information	RRID:IMSR_EM:16222 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	BALB/cN-Nxnl1^tm1.1Ics/Ics
Alternative name	Nxnl1tm1.1/Ics
Strain type	Targeted Mutant Strains : Point mutation
Allele/Transgene symbol	Nxnl1^tm1.1Ics
Gene/Transgene symbol	Nxnl1

Information from provider

Provider	Thierry Léveillard
Provider affiliation	Institut de la Vision, INSERM UMR_S 968, CNRS UMR_7210, Sorbonne Université
Genetic information	A floxed auto-excisable selection cassette (neoR-protamine cre) was inserted upstream exon 2 (ENSMUSE00000914521, Nxnl1-201 GRCm39); glutamine codon 114 (CAG) in exon 2 was changed to a premature STOP codon (TAG; c.340C>T p.Q>*).
Phenotypic information	Homozygous: N/A Heterozygous: N/A
Breeding history	100% BALB/cNCrl
References	None available
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

MGI phenotypes (gene matching)

abnormal vision / MGI
abnormal lipid homeostasis / MGI
no phenotypic analysis / MGI
abnormal rod electrophysiology / MGI
abnormal cone electrophysiology / MGI
abnormal eye physiology / MGI
decreased retinal cone cell number / MGI
thin retinal outer nuclear layer / MGI
microgliosis / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.
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BALB/cN-Nxnl1tm1.1Ics/Ics