FVB/NPas-Tg(H2-Db)2Bujf/Orl
| Status | Available to order |
| EMMA ID | EM:01631 |
| Citation information | RRID:IMSR_EM:01631 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | FVB/NPas-Tg(H2-Db)2Bujf/Orl |
| Alternative name | FVB H2-Db2 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(H2-Db)2Bujf |
| Gene/Transgene symbol | Tg(H2-Db)2Bujf |
Information from provider
| Provider | Bureau Jean-François Bureau Jean-François |
| Provider affiliation | Pasteur Institute |
| Genetic information | The transgene was a 10 kb HindIII restriction fragment of genomic DNA containing the entire H2-Db gene (eight exons), more than 4 kb of the 5-prime flanking DNA, and approximately 1 kb of downstream DNA. Transgenesis has been performed on inbred FVB/N mice at Pasteur Institute animal facility (C. Babinet). |
| Phenotypic information | FVB mice expressing the H2-Db gene. FVB mice susceptible to the persistence of Theiler's virus become resistant. |
| Breeding history | The FVB/N heterozygous for H2-Db gene were intercrossed and transgenic animals were bred for more than 10 generations. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Literature references
- FVB mice transgenic for the H-2Db gene become resistant to persistent infection by Theiler's virus.;Azoulay A, Brahic M, Bureau J F, ;1994;Journal of virology;68;4049-52; 8189541
- Roles of the H-2D(b) and H-K(b) genes in resistance to persistent Theiler's murine encephalomyelitis virus infection of the central nervous system.;Azoulay-Cayla Arièle, Syan Sylvie, Brahic Michel, Bureau Jean-François, ;2001;The Journal of general virology;82;1043-1047; 11297678