- decreased circulating alkaline phosphatase level / IMPC
- abnormal ear morphology / IMPC
- increased grip strength / IMPC
- male infertility / IMPC
- increased freezing behavior / IMPC
- increased blood urea nitrogen level / IMPC
- decreased prepulse inhibition / IMPC
- increased circulating cholesterol level / IMPC
C3Fe;B6J-Prkrarep/Orl
| Status | Available to order |
| EMMA ID | EM:01640 |
| Citation information | RRID:IMSR_EM:01640 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3Fe;B6J-Prkrarep/Orl |
| Alternative name | Small ear (Sme) |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Prkrarep |
| Gene/Transgene symbol | Prkra |
Information from provider
| Provider | Yann HERAULT |
| Provider affiliation | TAAM-CDTA UPS44, CNRS-TAAM – Typing and Archiving of Animal Models |
| Genetic information | Strain obtained from an ENU recessive screen. |
| Phenotypic information | Pinna is smaller and the mutant mice are smaller. |
| References |
|
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Dystonia 16 / Orphanet_210571
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- small ears / MGI
- abnormal middle ear morphology / MGI
- abnormal neurocranium morphology / MGI
- short snout / MGI
- decreased body weight / MGI
- decreased body size / MGI
- postnatal growth retardation / MGI
- reduced fertility / MGI
- infertility / MGI
- female infertility / MGI
- abnormal outer ear morphology / MGI
- small interparietal bone / MGI
- short nasal bone / MGI
- turbinate hypoplasia / MGI
- abnormal middle ear ossicle morphology / MGI
- vision/eye phenotype / MGI
- abnormal external auditory canal morphology / MGI
- impaired hearing / MGI
- embryonic lethality before implantation, complete penetrance / MGI
- increased or absent threshold for auditory brainstem response / MGI
- wide cranial sutures / MGI
- round snout / MGI
- small mandibular condyloid process / MGI
- abnormal temporal bone zygomatic process morphology / MGI
- small mandibular coronoid process / MGI
Literature references
- Missense mutation in the second RNA binding domain reveals a role for Prkra (PACT/RAX) during skull development.;Dickerman Benjamin K, White Christine L, Chevalier Claire, Nalesso Valérie, Charles Cyril, Fouchécourt Sophie, Guillou Florian, Viriot Laurent, Sen Ganes C, Hérault Yann, ;2011;PloS one;6;e28537; 22194846
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