C3Fe;B6J-Prkrarep/Orl

Status

Available to order

EMMA IDEM:01640
Citation informationRRID:IMSR_EM:01640 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

International strain nameC3Fe;B6J-Prkrarep/Orl
Alternative nameSmall ear (Sme)
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolPrkrarep
Gene/Transgene symbolPrkra

Information from provider

ProviderYann HERAULT
Provider affiliationTAAM-CDTA UPS44, CNRS-TAAM – Typing and Archiving of Animal Models
Genetic informationStrain obtained from an ENU recessive screen.
Phenotypic informationPinna is smaller and the mutant mice are smaller.
References
  • Missense mutation in the second RNA binding domain reveals a role for Prkra (PACT/RAX) during skull development.;Dickerman Benjamin K, White Christine L, Chevalier Claire, Nalesso Valérie, Charles Cyril, Fouchécourt Sophie, Guillou Florian, Viriot Laurent, Sen Ganes C, Hérault Yann, ;2011;PloS one;6;e28537; 22194846

Information from EMMA

Archiving centreCNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased circulating alkaline phosphatase level / IMPC
  • abnormal ear morphology / IMPC
  • increased grip strength / IMPC
  • male infertility / IMPC
  • increased freezing behavior / IMPC
  • increased blood urea nitrogen level / IMPC
  • decreased prepulse inhibition / IMPC
  • increased circulating cholesterol level / IMPC
MGI phenotypes (allele matching)
  • short nasal bone / MGI
  • small ears / MGI
  • decreased body weight / MGI
  • postnatal growth retardation / MGI
  • female infertility / MGI
  • small mandibular condyloid process / MGI
  • abnormal temporal bone zygomatic process morphology / MGI
  • small mandibular coronoid process / MGI
MGI phenotypes (gene matching)
  • small ears / MGI
  • abnormal middle ear morphology / MGI
  • abnormal neurocranium morphology / MGI
  • short snout / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • postnatal growth retardation / MGI
  • reduced fertility / MGI
  • infertility / MGI
  • female infertility / MGI
  • abnormal outer ear morphology / MGI
  • small interparietal bone / MGI
  • short nasal bone / MGI
  • turbinate hypoplasia / MGI
  • abnormal middle ear ossicle morphology / MGI
  • vision/eye phenotype / MGI
  • abnormal external auditory canal morphology / MGI
  • impaired hearing / MGI
  • embryonic lethality before implantation, complete penetrance / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • wide cranial sutures / MGI
  • round snout / MGI
  • small mandibular condyloid process / MGI
  • abnormal temporal bone zygomatic process morphology / MGI
  • small mandibular coronoid process / MGI

Literature references

  • Missense mutation in the second RNA binding domain reveals a role for Prkra (PACT/RAX) during skull development.;Dickerman Benjamin K, White Christine L, Chevalier Claire, Nalesso Valérie, Charles Cyril, Fouchécourt Sophie, Guillou Florian, Viriot Laurent, Sen Ganes C, Hérault Yann, ;2011;PloS one;6;e28537; 22194846

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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