IMPC phenotypes (gene matching)
B6.129X1-Ncoa6tm1Pera/PeraKieg
| Status | Available to order |
| EMMA ID | EM:00165 |
| Citation information | RRID:IMSR_EM:00165 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129X1-Ncoa6tm1Pera/PeraKieg |
| Alternative name | RAP250, RAP250 KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ncoa6tm1Pera |
| Gene/Transgene symbol | Ncoa6 |
Information from provider
| Provider | Per Antonson |
| Provider affiliation | Department of Bioscience, Karolinska Institutet |
| Genetic information | Exon 7 and 8 of the Ncoa6 (RAP250) gene were deleted and replaced by the neo gene. |
| Phenotypic information | Embryonic lethal at E13.5 due to placental dysfunction. Embryos have defects in heart and brain development. |
| Breeding history | Backcrossed 8 times to C57BL/6. |
| References |
|
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Disease and phenotype information
MGI phenotypes (allele matching)
- thin ventricular wall / MGI
- trabecula carnea hypoplasia / MGI
- dilated third ventricle / MGI
- abnormal thalamus morphology / MGI
- abnormal hypothalamus morphology / MGI
- abnormal placenta morphology / MGI
- delayed brain development / MGI
- disorganized myocardium / MGI
- thin myocardium / MGI
- abnormal placenta vasculature / MGI
- absent olfactory bulb / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- decreased neuron number / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- decreased spongiotrophoblast size / MGI
MGI phenotypes (gene matching)
- abnormal triglyceride level / MGI
- abnormal vascular development / MGI
- abnormal heart morphology / MGI
- abnormal heart development / MGI
- thin ventricular wall / MGI
- trabecula carnea hypoplasia / MGI
- decreased hair follicle number / MGI
- oligodactyly / MGI
- abnormal liver development / MGI
- abnormal liver morphology / MGI
- small liver / MGI
- decreased hepatocyte number / MGI
- abnormal hepatocyte morphology / MGI
- dilated third ventricle / MGI
- abnormal hypothalamus morphology / MGI
- abnormal brain development / MGI
- thick epidermis / MGI
- abnormal lens morphology / MGI
- cataract / MGI
- small lens / MGI
- abnormal eye pigmentation / MGI
- abnormal blood vessel morphology / MGI
- decreased embryo size / MGI
- abnormal placenta morphology / MGI
- abnormal placenta development / MGI
- impaired wound healing / MGI
- delayed brain development / MGI
- reduced male fertility / MGI
- reduced female fertility / MGI
- female infertility / MGI
- decreased litter size / MGI
- abnormal digit morphology / MGI
- abnormal lipid homeostasis / MGI
- disorganized myocardium / MGI
- thin myocardium / MGI
- heart hypoplasia / MGI
- delayed wound healing / MGI
- increased liver weight / MGI
- abnormal epicardium morphology / MGI
- abnormal vitelline vasculature morphology / MGI
- abnormal placenta vasculature / MGI
- abnormal embryonic hematopoiesis / MGI
- absent placental labyrinth / MGI
- absent olfactory bulb / MGI
- abnormal fetal cardiomyocyte proliferation / MGI
- pallor / MGI
- abnormal feces composition / MGI
- increased hepatocyte apoptosis / MGI
- embryonic growth retardation / MGI
- thin myocardium compact layer / MGI
- abnormal spongiotrophoblast layer morphology / MGI
- dilated vasculature / MGI
- abnormal trophoblast layer morphology / MGI
- increased circulating cholesterol level / MGI
- abnormal heart ventricle morphology / MGI
- pericardial effusion / MGI
- abnormal myocardium layer morphology / MGI
- abnormal bile salt homeostasis / MGI
- reproductive system phenotype / MGI
- abnormal cell physiology / MGI
- impaired placental function / MGI
- abnormal fetal cardiomyocyte morphology / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- decreased neuron number / MGI
- abnormal spongiotrophoblast cell morphology / MGI
- decreased erythroid progenitor cell number / MGI
- increased trophoblast giant cell number / MGI
- decreased birth weight / MGI
- decreased birth body size / MGI
- abnormal palatal shelf fusion at midline / MGI
- neonatal lethality, incomplete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- decreased fibroblast proliferation / MGI
- decreased spongiotrophoblast size / MGI
- abnormal liver bud morphology / MGI
- increased sebaceous gland number / MGI
- increased fibroblast apoptosis / MGI
- small thalamus / MGI
Literature references
- Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction.;Antonson Per, Schuster Gertrud U, Wang Ling, Rozell Björn, Holter Elin, Flodby Per, Treuter Eckardt, Holmgren Lars, Gustafsson Jan-Ake, ;2003;Molecular and cellular biology;23;1260-8; 12556486