B6;129-Rttn^{Gt(pGT1.8geo)7Pgr}/PgrKieg

Status	Available to order
EMMA ID	EM:00167
Citation information	RRID:IMSR_EM:00167 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6;129-Rttn^{Gt(pGT1.8geo)7Pgr}/PgrKieg
Alternative name	Rotatin XV-53, Rotatin-gt, B6;129/SvR1-RotGt(pGT1.8geo)XV-53
Strain type	Gene-trap
Allele/Transgene symbol	Rttn^{Gt(pGT1.8geo)7Pgr}
Gene/Transgene symbol	Rttn

Information from provider

Provider	Peter Gruss
Provider affiliation	Max Planck Inst. Biophysical Chemistry
Genetic information	Integration of gene trap vector pGT1.8 neo at nt 1101 of the rotatin coding sequence.
Phenotypic information	Defects in L-R specification. Homozygous embryos: at E9.5 are delayed in development; axial rotation not completed or just started; at E11.5, heart beating stopped in two-third of the embryos, randomized heart looping.
References	Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos.;Faisst Anja M, Alvarez-Bolado Gonzalo, Treichel Dieter, Gruss Peter, ;2002;Mechanisms of development;113;15-28; 11900971

Information from EMMA

Archiving centre	Karolinska Institutet, Stockholm, Sweden

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Microcephalic primordial dwarfism due to RTTN deficiency / Orphanet_468631

IMPC phenotypes (gene matching)

small heart / IMPC
prenatal lethality prior to heart atrial septation / IMPC
preweaning lethality, complete penetrance / IMPC
abnormal stomach morphology / IMPC
abnormal skin morphology / IMPC
abnormal embryo size / IMPC
abnormal liver morphology / IMPC
decreased bone mineral content / IMPC
abnormal spleen morphology / IMPC
enlarged urinary bladder / IMPC
embryonic growth retardation / IMPC

MGI phenotypes (allele matching)

abnormal somite development / MGI
decreased embryo size / MGI
abnormal embryo turning / MGI
abnormal neural tube morphology / MGI
failure of initiation of embryo turning / MGI
abnormal direction of heart looping / MGI
notochord degeneration / MGI
pericardial effusion / MGI
embryonic lethality during organogenesis, complete penetrance / MGI

MGI phenotypes (gene matching)

abnormal embryo development / MGI
abnormal somite development / MGI
decreased embryo size / MGI
abnormal embryo turning / MGI
abnormal neural tube morphology / MGI
failure of initiation of embryo turning / MGI
abnormal direction of heart looping / MGI
notochord degeneration / MGI
pericardial effusion / MGI
embryonic lethality during organogenesis, complete penetrance / MGI

Literature references

Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos.;Faisst Anja M, Alvarez-Bolado Gonzalo, Treichel Dieter, Gruss Peter, ;2002;Mechanisms of development;113;15-28; 11900971

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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