IMPC phenotypes (allele matching)
STOCK Rasgrf1tm1bNarl/H
| Status | Available to order |
| EMMA ID | EM:16765 |
| Citation information | RRID:IMSR_EM:16765 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Rasgrf1tm1bNarl/H |
| Alternative name | STOCK Rasgrf1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Rasgrf1tm1bNarl |
| Gene/Transgene symbol | Rasgrf1 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | The targeting construct inserted upstream of exon 2 an FRT site, En2 splice acceptor, IRES sequence, lacZ reporter gene, SV40 polyadenylation sequence, loxP site, neomycin resistance cassette, and loxP site. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 along with the reporter and selection cassettes. |
| Phenotypic information | Homozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.orgHeterozygous:These mice are part of the International Mouse Phenotyping Consortium (IMPC) and will be phenotyped through a standardised phenotyping pipeline. Details of the pipeline and data, when available, can be viewed at www.mousephenotype.org |
| Breeding history | The tm1a mice were imported on n undefined C57BL/6 background. The strain has since been converted to a tm1b and maintained on a C57BL/6NTac USA background |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased body weight / MGI
- abnormal spatial learning / MGI
- reduced long term potentiation / MGI
- postnatal growth retardation / MGI
- abnormal pituitary secretion / MGI
- impaired synaptic plasticity / MGI
- no abnormal phenotype detected / MGI
- decreased circulating insulin level / MGI
- abnormal active avoidance behavior / MGI
- abnormal discrimination learning / MGI
- abnormal excitatory postsynaptic potential / MGI
- impaired social transmission of food preference / MGI
- no phenotypic analysis / MGI
- maternal imprinting / MGI
- paternal imprinting / MGI
- decreased pancreatic beta cell number / MGI
- nervous system phenotype / MGI
- abnormal imprinting / MGI
- decreased circulating insulin-like growth factor I level / MGI
- decreased growth hormone level / MGI
- impaired glucose tolerance / MGI
- behavior/neurological phenotype / MGI
- enhanced lipolysis / MGI
- abnormal long term spatial reference memory / MGI
- abnormal DNA methylation / MGI
- small pancreatic islets / MGI
- impaired contextual conditioning behavior / MGI
- decreased total body fat amount / MGI