C3;C-Aff1Rob/H

Status

Available to order

EMMA IDEM:01681
Citation informationRRID:IMSR_EM:01681 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC3;C-Aff1Rob/H
Alternative nameAff1<Rob>
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolAff1Rob
Gene/Transgene symbolAff1

Information from provider

ProviderPat Nolan
Provider affiliationMRC Mammalian Genetics Unit
Genetic informationPoint mutation causing transition of T to C in the second base of codon 280 of the AF4/FMRS family, member 1 (Aff1) gene.
Phenotypic informationHeterozygotes exhibit small size, robotic like, jerky movements (ataxia) and elevated tail when moving, adult-onset Purkinje neuron loss, cataracts, reduced survival, and low fertility.
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal cerebellum morphology / MGI
  • Purkinje cell degeneration / MGI
  • thin cerebellar molecular layer / MGI
  • decreased body size / MGI
  • cataract / MGI
  • abnormal stationary movement / MGI
  • ataxia / MGI
  • impaired balance / MGI
  • thymus hypoplasia / MGI
  • reduced male fertility / MGI
  • female infertility / MGI
  • gliosis / MGI
  • abnormal double-negative T cell morphology / MGI
  • decreased thymus weight / MGI
  • jerky movement / MGI
  • preweaning lethality, incomplete penetrance / MGI
MGI phenotypes (gene matching)
  • abnormal immune system cell morphology / MGI
  • abnormal cerebellum morphology / MGI
  • Purkinje cell degeneration / MGI
  • thin cerebellar molecular layer / MGI
  • decreased body size / MGI
  • cataract / MGI
  • abnormal stationary movement / MGI
  • ataxia / MGI
  • impaired balance / MGI
  • thymus hypoplasia / MGI
  • reduced male fertility / MGI
  • female infertility / MGI
  • abnormal T cell differentiation / MGI
  • gliosis / MGI
  • abnormal double-negative T cell morphology / MGI
  • abnormal immune system organ morphology / MGI
  • no phenotypic analysis / MGI
  • decreased thymus weight / MGI
  • decreased B cell number / MGI
  • decreased double-positive T cell number / MGI
  • jerky movement / MGI
  • decreased single-positive T cell number / MGI
  • decreased pre-B cell number / MGI
  • decreased mature B cell number / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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