IMPC phenotypes (gene matching)
B6;CBA-Kdelr2em2Vlrp/Cnbc
| Status | Available to order |
| EMMA ID | EM:17003 |
| Citation information | RRID:IMSR_EM:17003 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;CBA-Kdelr2em2Vlrp/Cnbc |
| Alternative name | Kdelr2em2/Cnbc |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Kdelr2em2Vlrp |
| Gene/Transgene symbol | Kdelr2 |
Information from provider
| Provider | Víctor L. Ruiz |
| Provider affiliation | Molecular Genetic and Rare Diseases, Instituto de Investigaciones Biomédicas Sols-Morreale(CSIC-UAM) |
| Genetic information | This mutation is a 2-bp deletion in exon 4 of the Kdelr2 gene, causing a frameshift and a premature termination codon. NM_025841.4:c.400_401delCA; p.(Gln134AlafsTer11). |
| Phenotypic information | Homozygous:Kdelr2em2/Cnbc homozygous mutant mice show neonatal lethality and at E18.5 were found to have bones of reduced length and delayed ossification.Heterozygous:Heterozygous mice show no phenotypic alterations. |
| Breeding history | Mice were initially generated by microinjecting CRISPR/Cas9 reagents into fertilized B6CBAF2 eggs. Subsequently, the strain was maintained by crossing heterozygous males to C57BL/6J wild-type females for more than 5 generations. |
| References | None available |
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |