D2.Cg-Tg(TG-Gnas*R201H)1Rho/Orl

Status	Available to order
EMMA ID	EM:01721
Citation information	RRID:IMSR_EM:01721 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	D2.Cg-Tg(TG-Gnas*R201H)1Rho/Orl
Alternative name	2211D
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(TG-Gnas*R201H)1Rho
Gene/Transgene symbol	Tg(TG-Gnas*R201H)1Rho

Information from provider

Provider	Jean FEUNTEUN
Provider affiliation	Institut Gustave Roussy-UMR 8125
Genetic information	Transgene containing the guanine nucleotide binding protein G-S alpha subunit (Gnas) sequence carrying the mutation Arg 201 to His.
Breeding history	Heterozygotes were crossed to DBA/2 wild-type mice for 60 generations.
References	Oncogenic potential of guanine nucleotide stimulatory factor alpha subunit in thyroid glands of transgenic mice.;Michiels F M, Caillou B, Talbot M, Dessarps-Freichey F, Maunoury M T, Schlumberger M, Mercken L, Monier R, Feunteun J, ;1994;Proceedings of the National Academy of Sciences of the United States of America;91;10488-92; 7937980 Loss of FADD protein expression results in a biased Fas-signaling pathway and correlates with the development of tumoral status in thyroid follicular cells.;Tourneur Léa, Mistou Sylvie, Michiels Francine-Marie, Devauchelle Valérie, Renia Laurent, Feunteun Jean, Chiocchia Gilles, ;2003;Oncogene;22;2795-804; 12743602

Information from EMMA

Archiving centre	CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France

Literature references

Oncogenic potential of guanine nucleotide stimulatory factor alpha subunit in thyroid glands of transgenic mice.;Michiels F M, Caillou B, Talbot M, Dessarps-Freichey F, Maunoury M T, Schlumberger M, Mercken L, Monier R, Feunteun J, ;1994;Proceedings of the National Academy of Sciences of the United States of America;91;10488-92; 7937980
Loss of FADD protein expression results in a biased Fas-signaling pathway and correlates with the development of tumoral status in thyroid follicular cells.;Tourneur Léa, Mistou Sylvie, Michiels Francine-Marie, Devauchelle Valérie, Renia Laurent, Feunteun Jean, Chiocchia Gilles, ;2003;Oncogene;22;2795-804; 12743602

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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Material Transfer Agreement (MTA)
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EMMA conditions
Legally binding conditions for the transfer

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