C.Cg-Tg(H2-Ea-LACK)1Ngkh/Orl
| Status | Available to order |
| EMMA ID | EM:01737 |
| Citation information | RRID:IMSR_EM:01737 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C.Cg-Tg(H2-Ea-LACK)1Ngkh/Orl |
| Alternative name | IE-LACK |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(H2-Ea-LACK)1Ngkh |
| Gene/Transgene symbol | Tg(H2-Ea-LACK)1Ngkh |
Information from provider
| Provider | Nicolas Glaichenhaus |
| Provider affiliation | INSERM U561 - Hopital Saint Vincent de Paul, Paris |
| Genetic information | A truncated LACK (Leishmania homolog of receptors for activated C kinase) cDNA was cloned under the control of the major histocompatibility complex class II I-E-alpha promoter using the pDOI-5 plasmid provided by D. Mathis. The N-terminal part of the LACK protein expressed from this construct contains an hemagglutinin (HA) epitope which is recognized by the monoclonal antibody 12CA5. This allows the detection of the LACK protein by Western blot. |
| Phenotypic information | No defects. |
| Breeding history | The original mouse strain was bred for 12 generations on BALB/c genetic background. Mice have then been made homozygous for the LACK transgene and the strain is maintained by sister-brother matings. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Literature references
- Resistance to Leishmania major induced by tolerance to a single antigen.;Julia V, Rassoulzadegan M, Glaichenhaus N, ;1996;Science (New York, N.Y.);274;421-3; 8832890
- CD4(+) T cells which react to the Leishmania major LACK antigen rapidly secrete interleukin-4 and are detrimental to the host in resistant B10.D2 mice.;Julia V, Glaichenhaus N, ;1999;Infection and immunity;67;3641-4; 10377151
- T-cell responses to immunodominant LACK antigen do not play a critical role in determining susceptibility of BALB/c mice to Leishmania mexicana.;Torrentera F A, Glaichenhaus N, Laman J D, Carlier Y, ;2001;Infection and immunity;69;617-21; 11119565